昼夜节律紊乱与2型糖尿病关系的研究进展  

Progress in the Study of the Relationship between Circadian Rhythm Disruption and Type 2 Diabetes Mellitus

作　　者：陈筵明 龚维坤 孙英芬 朱琼 蔡婕[3] 蒋静 季林丹[5,6] 徐进 CHEN Yanming;GONG Weikun;SUN Yingfen;ZHU Qiong;CAI Jie;JIANG Jing;JI Lindan;XU Jin(Department of Preventive Medicine,Ningbo University School of Medicine,Ningbo 315211,China;Yinzhou Hospital,Ningbo University Medicine,Ningbo 315040,China;Ningbo Women and Children Hospital,Ningbo 315012,China;Department of Clinical Medicine,Ningbo University School of Medicine,Ningbo 315211,China;Department of Biochemistry and Molecular Biology,Ningbo University School of Medicine,Ningbo 315211,China;Zhejiang Key Laboratory of Pathophysiology Technology Research,Ningbo 315211,China)

机构地区：[1]宁波大学医学院预防医学系,宁波315211 [2]宁波大学医学院附属鄞州医院,宁波315040 [3]宁波市妇女儿童医院,宁波315012 [4]宁波大学医学院临床医学系,宁波315211 [5]宁波大学医学院生物化学与分子生物学系,宁波315211 [6]浙江省病理生理学技术研究重点实验室,宁波315211

出　　处：《中国细胞生物学学报》2020年第9期1684-1693,共10页Chinese Journal of Cell Biology

基　　金：浙江省公益技术应用研究计划(批准号:LGF20H260009、LGF20H040005);浙江省医药卫生科技计划(批准号:2019KY648);宁波市公益类科技计划(批准号:2019C50097)资助的课题。

摘　　要：昼夜节律是生物体内部普遍存在的固有生物节律之一,有利于机体适应外部明/暗环境。近年来研究发现,血糖代谢及相关激素分泌等生理过程具有昼夜节律,正常时与睡眠周期、光线模式、摄食及日常锻炼同步;而当机体长期处于夜班轮班、跨时区旅行等状态造成昼夜节律紊乱,可引起血糖紊乱等一系列问题,显著增加2型糖尿病发病风险。相关机制可能涉及血糖代谢、激素调控、生活方式、节律基因多态性及药物代谢等的昼夜节律变化和相关病理生理过程。该文将依据当前流行病学调查、病理生理学及遗传学研究来系统阐述昼夜节律紊乱在2型糖尿病发生、发展中的作用,为今后2型糖尿病的综合防治提供新思路。Circadian rhythm as an important inherent biological rhythm exists in all living organisms,facilitating them to adapt to the external light/dark environment.Recent studies reveal that both glucose metabolism and associated hormone secretion demonstrate obvious circadian rhythm patterns.Normally,it is synchronized with,sleep cycle,light pattern,food intake and daily exercise models.However,when there is a circadian rhythm disorder due to night shift work or jet lag caused by cross-time zone travel,etc.,it may result in a series of healthy problems especially glucose metabolism disorder which can significantly increase the risk of type 2 diabetes mellitus.The mechanisms probably involve circadian variation and pathophysiological processes of glucose metabolism,hormone regulation,lifestyle,rhythm gene polymorphisms,drug metabolism,etc.This paper will systematically review the role of circadian rhythm in the occurrence and development of type 2 diabetes mellitus based on the current knowledge of associated epidemiological,pathophysiological and genetical studies,providing new ideas for future comprehensive prevention and treatment of type 2 diabetes mellitus.

关 键 词：昼夜节律 2型糖尿病 糖代谢 轮班 

分 类 号：R587.1[医药卫生—内分泌]