Piezo机械敏感性离子通道在胃肠道中的表达及功能  

Expression and Function of Mechanosensitive Ion Channel Piezo in the Gastrointestinal Tract

作　　者：于天卓 高瑞桐 李峰[1] YU Tianzhuo;GAO Ruitong;LI Feng(Department of Internal Medicine,School of Nursing,Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学护理学院内科教研室,长春130021

出　　处：《中国细胞生物学学报》2020年第9期1700-1705,共6页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:81570491)资助的课题。

摘　　要：Piezo是一类新型的机械敏感性通道蛋白,可以感受细胞膜机械力变化,对细胞机械敏感性至关重要。肠上皮嗜铬细胞、肠平滑肌细胞和Cajal间质细胞等胃肠道机械敏感性细胞均可通过机械敏感性离子通道来响应机械力,影响胃肠道的生理功能。该文就Piezo在组织器官中的表达及功能进行介绍,重点阐述Piezo在胃肠道各组织中的表达及功能,探讨Piezo对在生理及病理条件下的胃肠道产生的作用及影响。Piezo is a new class of mechanosensitive channel proteins that can sense changes in cell membrane mechanical forces and is critical to cell mechanical sensitivity.Intestinal epithelial chromaffin cells,intestinal smooth muscle cells,and Cajal interstitial cells can all respond to mechanical forces through mechanically sensitive ion channels,affecting the gastrointestinal physiological functions.This article introduces the expression and function of Piezo in tissues and organs,focuses on the expression and function of Piezo in various tissues of the gastrointestinal tract,and discusses the effect and influence of Piezo on the gastrointestinal tract under physiological and pathological conditions.

关 键 词：Piezo1 Piezo2 机械敏感性离子通道 胃肠道 

分 类 号：R333[医药卫生—人体生理学]