自拟狼疮方联合泼尼松治疗系统性红斑狼疮患者疗效及对激素用量和不良反应的影响  

The curative effect of self-made lupus prescription combined with prednisone in the treatment of patients with systemic lupus erythematosus and its influences on hormone dosage and adverse reactions

作　　者：岳峰[1] 崔丽敏[5] 张珍 安巨会[3] 刘东海[4] 周文花[1] YUE Feng;CUI Li-min;ZHANG Zhen;AN Ju-hui;LIU Dong-hai;ZHOU Wen-hua(Department of Rheumatology and Immunology,Langfang People's Hospital,Langfang 065000,China;Outpatient Office,Langfang People's Hospital,Langfang 065000,China;Department of Cardiology,Langfang People's Hospital,Langfang 065000,China;Department of Dermatology,Langfang People's Hospital,Langfang 065000,China;Department of Obstetrics and Screening,Langfang Maternal and Child Health Care Center,Langfang 065000,China)

机构地区：[1]河北省廊坊市人民医院风湿免疫科,河北廊坊065000 [2]河北省廊坊市人民医院门诊办公室,河北廊坊065000 [3]河北省廊坊市人民医院心内科,河北廊坊065000 [4]河北省廊坊市人民医院皮肤科,河北廊坊065000 [5]河北省廊坊市妇幼保健中心产筛科,河北廊坊065000

出　　处：《实用医院临床杂志》2020年第6期109-112,共4页Practical Journal of Clinical Medicine

基　　金：廊坊市科技局科研基金资助项目(编号:2017013142)。

摘　　要：目的探讨自拟狼疮方联合泼尼松治疗系统性红斑狼疮患者疗效及对激素用量和不良反应的影响。方法选取40例系统性红斑狼疮患者,按随机数字表法分为观察组与对照组各20例,对照组给予泼尼松治疗,观察组在对照组基础上联合使用自拟狼疮方,比较两组临床治疗有效率、临床症状、疾病活动度、糖皮质激素用量,随访复发率与不良反应发生情况。结果两组临床治疗有效率比较,差异无统计学意义(P>0.05);观察组治疗后持续低热、面手部红斑、脱发、五心烦热、口干咽燥、腰酸膝软、关节肌肉隐痛、心悸评分低于对照组(P<0.05);观察组治疗后1、2、3月疾病活动度SLEDAI评分低于对照组,治疗后6月糖皮质激素用量少于对照组,激素撤减量高于对照组(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05);两组随访3、6月复发率比较,差异无统计学意义(P>0.05)。结论自拟狼疮方联合泼尼松治疗系统性红斑狼疮可减少糖皮质激素使用量,改善患者临床症状,效果显著,安全性高。Objective To explore the curative effect of self-made lupus prescription combined with prednisone in the treatment of patients with systemic lupus erythematosus(SLE)and its influences on hormone dosage and adverse reactions.Methods Forty SLE patients in our hospital were enrolled.They were randomly divided into observation or control group,20 in each group.The control group was treated with prednisone while the observation group was additionally treated with self-made lupus prescription.The response rate of clinical treatment,clinical symptoms,disease activity,glucocorticoid dosage,recurrence rate during the period of follow-up and adverse reactions were compared between the two groups.Results There was no significant difference in the response rate of clinical treatment between the two groups(P>0.05).After treatment,scores of continuous low fever,erythema on face and hands,alopecia,dysphoria in chestpalms-soles,dry mouth and throat,soreness and weakness of waist and knees,dull pain of joint and muscle,and palpitation in the observation group were lower than those in the control group(P<0.05).After 1 month,2 and 3 months of treatment,scores of SLE disease activity index(SLEDAI)in the observation group were lower than those in the control group(P<0.05).After 6 months of treatment,glucocorticoid dosage in the observation group was lower than that in the control group while dosage of hormone withdrawal was more than that in the control group(P<0.05).There was no significant difference in incidence of adverse reactions between the two groups(P>0.05).There was no significant difference in recurrence rate between the two groups after 3 and 6 months of follow-up(P>0.05).Conclusion The self-made lupus prescription combined with prednisone in the treatment of SLE can reduce glucocorticoid dosage,and improve the clinical symptoms of patients.It has significant effects and high safety.

关 键 词：系统性红斑狼疮 泼尼松 自拟狼疮方 疗效 不良反应 

分 类 号：R593.24[医药卫生—内科学]