超声造影与^18F-FDG PET/CT判断多发性大动脉炎活动性的相关性  

Correlation between contrast-enhanced ultrasound and^18F-FDG PET/CT for judging activity of Takayasu arteritis

作　　者：陈洋[1] 张艳[1] 闫志华[2] 杨琦华 于瑞娜[1] CHEN Yang;ZHANG Yan;YAN Zhihua;YANG Qihua;YU Ruina(Department of Ultrasound,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Department of Nuclear Medicine,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Department of Rheumatology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院超声科,河南郑州450052 [2]郑州大学第一附属医院核医学科,河南郑州450052 [3]郑州大学第一附属医院风湿免疫科,河南郑州450052

出　　处：《中国医学影像技术》2020年第10期1470-1474,共5页Chinese Journal of Medical Imaging Technology

基　　金：河南省科技厅社会发展攻关项目(172102310048)。

摘　　要：目的探讨超声造影(CEUS)和^18F-FDG PET/CT在多发性大动脉炎(TA)活动性判断中的相关性。方法收集TA患者36例,均接受CEUS及^18F-FDG PET/CT检查,比较相关实验室指标及影像学参数,分析CEUS与^18F-FDG PET/CT评价TA活动性结果之间的相关性。结果CEUS明显增强组在病程、印度大动脉炎临床活动性评分(ITAS 2010)、颈动脉闭塞比、CEUS峰值强度、PET/CT视觉评分及最大标准摄取值(SUVmax)与对照组间差异存在统计学意义(P均<0.05);CEUS分级标准与PET/CT视觉评分呈中度相关(r=0.697,P<0.001),与临床活动性NIH标准及SUVmax均呈低度相关性(r=0.385,P=0.018;r=0.477,P=0.014);以^18F-FDG PET/CT视觉评分作为判断TA活动性的标准,临床活动性NIH标准的敏感度和特异度分别为0.783及0.769,CEUS的敏感度和特异度分别为1.000及0.846,AUC分别为0.776和0.923。结论CEUS判断TA活动性与^18F-FDG PET/CT存在明显正相关;以^18F-FDG PET/CT视觉评分作为TA活动性的判断标准,CEUS较临床活动性标准具有更高的敏感度和特异度,可作为判断TA活动性的有效指标。Objective To explore the correlation between contrast-enhanced ultrasound(CEUS)and^18F-FDG PET/CT for judging activity of Takayasu arteritis(TA).Methods A total of 36 TA patients who underwent CEUS and^18F-FDG PET/CT were enrolled,the related laboratory indexes and imaging parameters were compared.The correlation between CEUS and^18F-FDG PET/CT for judging TA activity was analyzed.Results There were significant differences of disease duration,Indian Takayasu arteritis clinical activity score(ITAS 2010),carotid occlusion ratio,CEUS peak intensity,PET/CT uptake and the maximal standardized uptake value(SUVmax)between CEUS significantly enhanced group and non-enhanced or little enhanced group(all P<0.05).CEUS was moderately correlated with PET/CT visual score(r=0.697,P<0.001)and slightly correlated with NIH criteria of clinical activity and SUVmax(r=0.385,P=0.018;r=0.477,P=0.014).Taken^18F-FDG PET/CT visual score as the criterion of TA activity,the sensitivity and specificity of NIH criteria of clinical activity was 0.783 and 0.769,of CEUS was 1.000 and 0.846,and AUC was 0.776 and 0.923,respectively.Conclusion Significant positive correlation existed between CEUS and^18F-FDG PET/CT for judging TA activity.Taken^18F-FDG PET/CT visual scoring as the standard,CEUS had higher sensitivity and specificity than clinical disease activity criteria,and might be used as an effective method for judging TA activity.

关 键 词：大动脉炎 氟脱氧葡萄糖F18 超声检查 介入性 正电子发射断层显像 

分 类 号：R543[医药卫生—心血管疾病] R445.1[医药卫生—内科学]