黄芩化学成分的研究  

Chemical constituents from Scutellaria baicalensis

作　　者：姚雪 程云霞[1,2] 陈龙 刘伟 王晓[1] 李奉胜 李兵 董红敬 YAO Xue;CHENG Yun-xia;CHEN Long;LIU Wei;WANG Xiao;LI Feng-sheng;LI Bing;DONG Hong-jing(Shandong Analysis and Test Center,Qilu University of Technology(Shandong Academy of Sciences),Jinan 250014,China;Shandong University of Traditional Chinese Medicine,Jinan 250300,China;Laiwu Ziguang Ecological Company,Jinan 271100,China;Lunan Pharmaceutical Group Co.,Ltd.,Linyi 276006,China)

机构地区：[1]齐鲁工业大学(山东省科学院),山东省分析测试中心,山东济南250014 [2]山东中医药大学药学院,山东济南250300 [3]莱芜紫光生态园有限公司,山东济南271100 [4]鲁南制药集团股份有限公司,山东临沂276006

出　　处：《中成药》2020年第11期2935-2940,共6页Chinese Traditional Patent Medicine

基　　金：国家自然科学基金青年基金(81803662);山东省自然科学基金博士基金(ZR2017BH018);“十三五”国家重点研发计划(2017YFC1700703);国家中药材产业技术体系(CARS-21);山东省科学院国际合作项目(2019GHZD07)。

摘　　要：目的研究黄芩Scutellaria baicalensis Georgi的化学成分。方法黄芩饮片90%乙醇提取物采用D101、Sephadex LH-20、ODS及半制备HPLC进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到14个化合物,分别鉴定为白杨素-6-C-α-L-吡喃阿拉伯糖-8-C-β-D-吡喃葡萄糖苷(1)、白杨素-6-C-β-D-吡喃葡萄糖-8-C-β-L-吡喃阿拉伯糖苷(2)、白杨素-6-C-β-D-吡喃葡萄糖-8-C-α-L-吡喃阿拉伯糖苷(3)、白杨素-6-C-β-L-吡喃阿拉伯糖-8-C-β-D-吡喃葡萄糖苷(4)、黄芩素-6-甲氧基-7-O-β-葡萄糖酸苷(5)、去甲汉黄芩素-7-O-β-葡萄糖酸苷(6)、二氢黄芩素-7-O-葡萄糖酸苷(7)、黄芩素-7-O-β-D-吡喃葡萄糖醛酸甲酯苷(8)、汉黄芩素-7-O-β-D-吡喃葡萄糖醛酸甲酯苷(9)、木蝴蝶苷A(10)、2′,4′-二羟基二氢查尔酮-3′-C-β-吡喃葡萄糖-6′-O-β-D-吡喃葡萄糖苷(11)、异夏佛塔苷(12)、白杨素-6,8-C-β-二吡喃葡萄糖苷(13)、千层纸素-7-O-β-D-吡喃葡萄糖醛酸甲酯苷(14)。结论化合物11~13为首次从该植物中分离得到。AIM To study the chemical constituents from Scutellaria baicalensis Georgi.METHODS The 90%ethanol extract of S.baicalensis was isolated and purified by D101,Sephadex LH-20,ODS and semi-prepara-tive HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Fourteen compounds were isolated and identified as chrysin-6-C-α-L-arabinopyranosyl-8-C-β-D-glucopyranoside(1),chrysin-6-C-β-D-glucopyranosyl-8-C-β-L-arabinopyranoside(2),chrysin-6-C-β-D-glu-copyranosyl-8-C-α-L-arabinopyranoside(3),chrysin-6-C-β-L-arabinopyranosyl-8-C-β-D-glucopyranoside(4),baicalein-6-methylether-7-O-β-glucuronide(5),norwogonin-7-O-β-glucuronide(6),dihydrobaicalein-7-O-glucu-ronide(7),baicalein-7-O-β-D-glucuronopyranoside methyl ester(8),wogonin-7-O-β-D-glucuronopyranoside methyl ester(9),oroxin A(10),2,4′-dihydroxydihydrochalcone-3′-C-β-glucopyranoside-6′-O-β-D-glucopyr-anoside(11),isoschaftoside(12),6,8-di-C-β-glucosylchrysin(13),and oroxylin-7-O-β-D-glucuronopyranoside methyl ester(14).CONCLUSION Compounds 11-13 are isolated from this plant for the first time.

关 键 词：黄芩 化学成分 分离鉴定 

分 类 号：R284.1[医药卫生—中药学]