2010年及2019年沈阳地区育龄期孕妇孕晚期血脂水平变化分析  

Analysis of serum lipid changes in pregnant women in Shenyang in 2010 and 2019

作　　者：宋贵玉[1] 王冰冰[1,2] 王丹 那全[1] 黄岭[1] 乔宠[1] SONG Guiyu;WANG Bingbing;WANG Dan;NA Quan;HUANG Ling;QIAO Chong(Department of Gynecology and Obstetrics,Shengjing Hospital,China Medical University,Shenyang 110004,China;Department of Gynecology and Obstetrics,General Hospital of Northern Theater Command,Shenyang 110016,China)

机构地区：[1]中国医科大学附属盛京医院妇产科,沈阳110004 [2]北部战区总医院妇产科,沈阳110016

出　　处：《中国医科大学学报》2020年第11期961-963,共3页Journal of China Medical University

基　　金：国家重点研发计划(2016YFC1000404);国家自然科学基金(81771610,81370735);国家自然科学基金青年基金(81300492,81601289);辽宁省特聘教授项目(2017);盛京自由研究者基金(201706)。

摘　　要：目的探讨沈阳地区10年前后育龄期孕妇孕晚期血脂水平变化情况。方法收集2010年及2019年在中国医科大学附属盛京医院足月分娩育龄期产妇的临床资料,共计5070例。按分娩时间将其分为2010年组和2019年组,于分娩前1周检测2组产妇晨起空腹静脉血中甘油三酯(TG)、胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)水平。结果2019年组产妇孕晚期TG、TC、HDL、LDL、ApoA、ApoB水平均明显高于2010年组[(3.57±1.52)mmol/L vs(3.22±1.55)mmol/L,P<0.01;(6.37±1.18)mmol/L vs(6.01±1.22)mmol/L,P<0.01;(1.89±0.43)mmol/L vs(1.83±0.43)mmol/L,P<0.01;(3.52±1.02)mmol/L vs(3.26±0.98)mmol/L,P<0.01;(2.29±0.39)mmol/L vs(1.97±0.38)mmol/L,P<0.01;(1.26±0.30)mmol/L vs(1.23±0.33)mmol/L,P<0.05]。2019年不同年龄层的产妇孕晚期TG、TC、HDL、LDL水平相较2010年亦均明显升高,且TG、TC水平随着孕产妇年龄增大逐渐升高。结论沈阳地区10年前后育龄期孕产妇孕晚期血脂水平出现明显升高,且TG、TC变化随孕产妇年龄增加而升高。Objective To investigate the changes in serum lipid levels in pregnant women in 2010 and 2019 in Shenyang.Methods A total of 5070 pregnant women were recruited at Shengjing Hospital of China Medical University in 2010 and 2019.The women were divided into the 2010 group and the 2019 group according to the year of delivery.The clinical data of the pregnant women were collected,and the levels of triglyceride(TG),total cholesterol(TC),high-density lipoprotein(HDL),low-density lipoprotein(LDL),apolipoprotein A1(ApoA1),and apolipoprotein B(ApoB)in the fasting serum of the two groups were detected at 1 week before delivery.Results The levels of TG,TC,HDL,LDL,ApoA1,and ApoB in the 2019 group were significantly higher than those in the 2010 group(3.57±1.52 vs.3.22±1.55 mmol/L,P<0.01;6.37±1.18 vs.6.01±1.22 mmol/L,P<0.01;1.89±0.43 vs.1.83±0.43 mmol/L,P<0.01;3.52±1.02 vs.3.26±0.98 mmol/L,P<0.01;2.29±0.39 vs.1.97±0.38 mmol/L,P<0.01;and 1.26±0.30 vs.1.23±0.33 mmol/L,P<0.05,respectively).The levels of TG,TC,HDL,and LDL in pregnant women of different ages were also significantly higher in the 2019 group than in the 2010 group,and the levels of TG and TC gradually increased with the increase in maternal age.Conclusion The serum lipid levels of pregnant women in late pregnancy significantly increased in the recent 10 years in Shenyang,and the changes of TG and TC levels increased with increasing maternal age.

关 键 词：胆固醇 甘油三酯 孕晚期 

分 类 号：R714.256[医药卫生—妇产科学]