阿托伐他汀配合钻孔引流术治疗对慢性硬膜下血肿患者血肿吸收及预后的影响  

Effect of Atorvastatin Combined with Drilling and Drainage on Hematoma Absorption and Prognosis in Patients with Chronic Subdural Hematoma

作　　者：王信国 陈娟 吴旺春 陈水钰 WANG Xinguo;CHEN Juan;WU Wangchun;CHEN Shuiyu(Affiliated Mindong Hospital of Fujian Medical University,Fu’an 355000,China)

机构地区：[1]福建医科大学附属闽东医院,福建福安355000

出　　处：《中外医学研究》2020年第30期138-140,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨阿托伐他汀配合钻孔引流术治疗对慢性硬膜下血肿(chronicsubdural hematoma,CSDH)患者血肿吸收及预后的影响。方法:回顾性分析2016年4月-2019年12月于本院就诊的60例CSDH患者的临床资料,按照治疗方法分为钻孔引流组与联合用药组,各30例。钻孔引流组行微创钻孔引流术治疗,联合用药组加用阿托伐他汀治疗。对比两组临床疗效、神经功能缺损情况、日常生活能力、并发症发生情况。结果:联合用药组治疗总有效率高于钻孔引流组(96.67% vs 73.33%),差异有统计学意义(P<0.05);两组治疗后日常生活能力量表(ADL)评分较治疗前明显升高,中国卒中量表(CSS)评分较治疗前明显降低,而联合用药组治疗后ADL评分高于钻孔引流组[(91.42±7.65)分 vs (84.65±6.85)分],CSS评分低于钻孔引流组[(16.35±3.42)分 vs (19.21±3.84)分],差异有统计学意义(P<0.05);联合用药组并发症发生率低于钻孔引流组(13.33% vs 36.67%),差异有统计学意义(P<0.05)。结论:阿托伐他汀配合钻孔引流术治疗CSDH可促进血肿吸收,减轻神经功能缺损,减少并发症,值得临床推广。Objective:To investigate the effect of Atorvastatin combined with drilling and drainage on hematoma absorption and prognosis in patients with chronic subdural hematoma (CSDH).Method:The clinical data of 60 CSDH patients admitted to our hospital from April 2016 to December 2019 were retrospectively analyzed.According to the treatment,they were divided into the drilled and drainage group and the combined medication group,each with 30 cases.The drilling and drainage group was treated with minimally invasive drilling and drainage,and the combined medication group was treated with Atorvastatin on the basic of the drilling and drainage group.The clinical efficacy,neurological deficit,daily life ability,and complications of the two groups were compared.Result:The total effective rate of the combination medication group was higher than that of the drilling and drainage group (96.67% vs 73.33%),the difference was statistically significant (P<0.05).The activity of daily living scale (ADL) score of the two groups after treatment was significantly higher than that before treatment,and the Chinese stroke scale (CSS) score of the two groups after treatment was lower than that before treatment.After treatment,the ADL score in the combined medication group was higher than that in the drilled and drainage group[(91.42±7.65) points vs (84.65±6.85) points],and the CSS score of the combined medication group was lower than that of the drilled and drainage group[(16.35±3.42) points vs (19.21±3.84) points],the differences were statistically significant (P<0.05).The incidence of complications in the combined medication group was lower than that in the drilling and drainage group (13.33% vs 46.67%),the difference was statistically significant (P<0.05).Conclusion:Atorvastatin combined with drilling and drainage for the treatment of CSDH can promote hematoma absorption,reduce neurological deficits and complications,and is worthy of clinical promotion.

关 键 词：慢性硬膜下血肿 钻孔引流术 阿托伐他汀 血肿吸收 神经功能缺损 日常生活能力 

分 类 号：R651.15[医药卫生—外科学]