组织因子在凝血及血栓与止血外的作用机制研究进展  

Role of Tissue Factors in Coagulation,Thrombosis and Hemostasis

作　　者：郑剑峰 邱洪[1] ZHENG Jianfeng;QIU Hong(Fu Wai Hospital,National Center for Cardiovascular Diseases,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100037,China)

机构地区：[1]中国医学科学院北京协和医学院国家心血管病中心阜外医院,北京100037

出　　处：《心血管病学进展》2020年第9期891-894,共4页Advances in Cardiovascular Diseases

摘　　要：组织因子是启动外源性凝血级联瀑布的关键因素,并在动脉粥样硬化斑块血栓形成中有重要作用。组织因子能以细胞相关蛋白、微粒和可溶性形式在血液中循环,在不同的细胞(甚至包括T淋巴细胞和血小板)和病理状态(如急性和慢性炎症状态)下,组织因子的表达也不相同,癌症可能会增强其表达和活性。除了凝血作用外,组织因子还是多种细胞的表面受体,参与许多细胞内信号、细胞存活、基因和蛋白表达、增殖、血管生成和肿瘤转移等机制。利用组织因子表达和/或活性调节的潜在治疗方式也被提出,开辟了医学治疗的新领域。现进一步论述组织因子的相关研究进展和作用机制。Tissue factor is the key factor to initiate the cascades of exogenous coagulation and plays an important role in atheromatous plaque thrombosis.Tissue factors circulate in the blood in the form of cell-associated proteins,particles and solubilities.Tissue factor expression is also different in different cells(including even T lymphocyte and platelets)and pathological states(such as acute and chronic inflammatory states),and cancer may enhance its expression and activity.In addition to its clotting function,tissue factor is also the surface receptor of various cells and participates the mechanisms in many intracellular signaling,cell survival,gene and protein expression,proliferation,angiogenesis and tumor metastasis.The potential therapeutic approaches using tissue factor expression and/or activity regulation have been proposed,opening up a new field of medical treatment.This review will discuss the mechanism of tissue factor and further summarize the relevant research progress.

关 键 词：组织因子 血栓与止血 细胞内信号 动脉粥样硬化 

分 类 号：R543.5[医药卫生—心血管疾病]