不同尿酸水平与心血管疾病之间的关系  

The Relationship Between Different Levels of Uric Acid and Cardiovascular Diseases

作　　者：蔺雅娟 杨晓蕾[1] 夏云龙[1] LIN Yajuan;YANG Xiaolei;XIA Yunlong(Department of Cardiology,The First Affiliated Hospital of Dalian Medical University,Dalian 116011,Liaoning,China)

机构地区：[1]大连医科大学附属第一医院心内科,辽宁大连116011

出　　处：《心血管病学进展》2020年第9期911-913,921,共4页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金(81900439/81970286)。

摘　　要：尿酸是人体中嘌呤经黄嘌呤氧化酶催化代谢的终产物。尿酸也被称为强效抗氧化剂,生理水平的尿酸能阻止H2O2诱导的超氧化物歧化酶的失活,从而维持超氧化物歧化酶活性,起到抗氧化的作用。然而最近多项研究表明,体内高尿酸血症与低尿酸血症均与多种心血管疾病的发生有关。现对体内不同程度尿酸水平与心血管疾病的发生做一综述。Uric acid is the final product of purine catalyzed metabolism in human body by xanthine oxidase.Uric acid is also known as a potent antioxidant.Physiological levels of uric acid can prevent the inactivation of H2 O2-induced superoxide dismutase,thus maintaining superoxide dismutase activity and playing an antioxidant role.However,a number of recent studies have shown that hyperuricemia and hypouricemia in vivo are associated with the occurrence of a variety of cardiovascular diseases.The purpose of this article is to review the occurrence of different levels of uric acid in vivo and cardiovascular diseases.

关 键 词：高尿酸血症 低尿酸血症 心血管疾病 

分 类 号：R54[医药卫生—心血管疾病]