丹参酮ⅡA磺酸钠联合马来酸桂哌齐特对突发性耳聋患者血液流变学、免疫功能及内耳微循环的影响  

Effects of tanshinoneⅡA sulfonate sodium combined with cinepazide maleate on hemorheology,immune function and inner ear microcirculation in patients with sudden deafness

作　　者：文科[1] 侯楠[1] 王轶 陈嘉[1] 邓玫[1] Wen Ke;Hou Nan;Wang Yi;Chen Jia;Deng Mei(Department of Otorhinolaryngology, The First Affiliated Hospital of Chengdu Medical College, Sichuan Province, Chengdu 610500,China)

机构地区：[1]成都医学院第一附属医院耳鼻喉科,610500

出　　处：《疑难病杂志》2020年第11期1138-1142,共5页Chinese Journal of Difficult and Complicated Cases

基　　金：四川省科技厅科研项目(19ZDYF0944);四川省教育厅科研项目(16ZB0274)。

摘　　要：目的观察丹参酮ⅡA磺酸钠注射液联合马来酸桂哌齐特对突发性耳聋患者血液流变学、免疫功能及内耳微循环的影响。方法选择2017年1月—2019年1月成都医学院第一附属医院耳鼻喉科收治突发性耳聋患者105例,依照随机数字表法分为对照组(52例)和观察组(53例)。2组均给予常规治疗,对照组加用马来酸桂哌齐特治疗,观察组给予丹参酮ⅡA磺酸钠注射液联合马来酸桂哌齐特治疗,治疗30 d后进行临床疗效评价。比较2组眩晕、耳鸣及耳闷消失时间,纯音听阈值、血液流变学指标(血浆黏度、全血高切黏度、全血低切黏度)、免疫功能指标[CD3+、CD4+T细胞水平和血清免疫球蛋白M(IgM)、免疫球蛋白G(IgG)]及内耳微循环指标[一氧化氮(NO)、内皮素(ET)、可溶性血管细胞黏附分子-1(sVCAM-1)、超氧化物歧化酶(SOD)],以及不良反应发生情况。结果观察组临床总有效率为94.34%,高于对照组的73.08%(χ^2/P=8.745/0.003)。观察组的眩晕、耳鸣及耳闷消失时间均明显短于对照组(t=4.630、10.705、9.053,P均=0.000)。治疗后观察组纯音听阈值小于对照组(t/P=10.798/0.000)。观察组治疗后血浆黏度、全血高切黏度、全血低切黏度、血清ET及sVCAM-1水平低于对照组(t=16.181、4.670、6.917、2.878、16.694,P均=0.000)。观察组外周血CD3+、CD4+、血清IgM、IgG、NO、SOD水平均高于对照组(t=4.455、2.982、7.299、10.155、3.515、5.059,P均=0.000)。治疗期间,2组均无严重的不良反应发生。结论突发性耳聋患者采用丹参酮ⅡA磺酸钠注射液联合马来酸桂哌齐特治疗疗效确切,能够提高免疫功能,改善临床症状、内耳微循环和血液流变学,且安全性较好。Objective To observe the effects of TanshinoneⅡA Sulfonate Sodium Injection combined with Cinepazide Maleate on hemorheology,immune function and inner ear microcirculation in patients with sudden deafness.Methods From January 2017 to January 2019,105 patients with sudden deafness were admitted to the Department of Otolaryngology,First Affiliated Hospital of Chengdu Medical College.According to the random number table,they were divided into control group(52 cases)and observation group(53 cases).Both groups received conventional treatment.The control group was treated with cinepazide maleate,and the observation group was treated with tanshinoneⅡA sodium sulfonate injection combined with cinepazide maleate.The clinical efficacy was evaluated 30 days after treatment.Compare the disappearance time of dizziness,tinnitus and ear fullness,pure tone hearing threshold,blood rheology index(plasma viscosity,whole blood high shear viscosity,whole blood low shear viscosity),immune function index[CD3+,CD4+T cell level And serum immunoglobulin M(IgM),immunoglobulin G(IgG)]and inner ear microcirculation indicators[nitric oxide(NO),endothelin(ET),soluble vascular cell adhesion molecule 1(sVCAM-1),superoxide Dismutase(SOD)],and the occurrence of adverse reactions.Results The total clinical effective rate in the observation group was 94.34%,which was higher than 73.08%in the control group(χ^2/P=8.745/0.003).The disappearance time of dizziness,tinnitus and ear fullness in the observation group was significantly shorter than that in the control group(t=4.630,10.705,9.053,all P=0.000).After treatment,the pure tone hearing threshold of the observation group was lower than that of the control group(t/P=10.798/0.000).After treatment,plasma viscosity,whole blood high shear viscosity,whole blood low shear viscosity,serum ET and sVCAM-1 levels in the observation group were lower than those in the control group(t=16.181,4.670,6.917,2.878,16.694,all P=0.000).The peripheral blood CD3+,CD4+,serum IgM,IgG,NO,SOD levels of the observation gro

关 键 词：突发性耳聋 丹参酮ⅡA磺酸钠 马来酸桂哌齐特 血液流变学 免疫功能 内耳微循环 

分 类 号：R76[医药卫生—耳鼻咽喉科]