细胞因子在系统性红斑狼疮中的研究进展  

Research progress of cytokines in systemic lupus erythematosus

作　　者：李淅萌(综述) 聂英坤(审校)[1] Li Ximeng;Nie Yingkun(The Second Affiliated Hospital of Harbin Medical University, Department of Rheumatology,Heilongjiang Province,Harbin 150000, China)

机构地区：[1]哈尔滨医科大学附属第二医院风湿免疫科,150000

出　　处：《疑难病杂志》2020年第11期1174-1178,共5页Chinese Journal of Difficult and Complicated Cases

基　　金：黑龙江省自然科学基金(D200975)。

摘　　要：系统性红斑狼疮是一种自身免疫性疾病,发病机制不明,主要与T、B细胞异常活跃,致病性自身抗体及免疫复合物异常沉积在组织和器官有关。细胞因子水平变化是系统性红斑狼疮发病的因素之一,并与疾病活动程度相关。近年来以多种细胞因子为靶点对系统性红斑狼疮进行治疗的方法逐步取得进展,细胞因子在系统性红斑狼疮中的研究价值越来越受到人们关注。文章就细胞因子在系统性红斑狼疮中的研究进展作一综述。Systemic lupus erythematosus is an autoimmune disease with an unknown pathogenesis,mainly related to abnormally active T and B cells,and abnormal deposition of pathogenic autoantibodies and immune complexes in tissues and organs.Changes in cytokine levels are one of the factors in the pathogenesis of systemic lupus erythematosus and are related to the degree of disease activity.In recent years,the treatment of systemic lupus erythematosus with multiple cytokines as targets has gradually made progress,and the research value of cytokines in systemic lupus erythematosus has attracted more and more attention.This article reviews the research progress of cytokines in systemic lupus erythematosus.

关 键 词：系统性红斑狼疮 细胞因子 发病机制 

分 类 号：R59[医药卫生—内科学]