四君子汤调节大鼠肠道菌群改善心肌肥厚诱导心力衰竭的研究  

Study of Sijunzi Decoction Improves Heart Failure Rat Model Induced by Myocardial Hypertrophy through Regulation of Gut Microbiota

作　　者：卢永康 陈窕圆[2] 庄贤勉 黄彬[2] LU Yong-kang;CHEN Tiao-yuan;ZHUANG Xian-mian;HUANG Bin(Cornary Heart Disease Center,Fuwai Hospital Chinese Academy of Medical Sciences,Shenzhen,Shenzhen 518000,China;Department of Gastroenterology,Shenzhen Traditional Chinese Medicine Hospital,Shenzhen 518000,China)

机构地区：[1]中国医学科学院阜外医院深圳医院冠心病中心,广东深圳518000 [2]深圳市中医院脾胃科,广东深圳518000

出　　处：《现代中药研究与实践》2020年第5期29-33,共5页Research and Practice on Chinese Medicines

基　　金：2017年度深圳市科技计划项目(JCYJ20170307155824718)。

摘　　要：目的基于四君子汤调节肠道菌群失衡的作用,探讨其治疗心肌肥厚诱导心力衰竭大鼠的效果。方法雄性大鼠分为假手术组、模型组、四君子汤组及益生菌组,通过缩窄腹主动脉制备心肌肥厚诱导心力衰竭的大鼠模型。给药前后均以超声评价心功能,给药后以高通量测序检测肠道菌群的变化,以及马松染色评估心肌肥厚。结果给药后,与模型组相比,四君子汤组肠道菌群失衡明显改善,表现为优势菌群增加,非优势菌群降低,并且心功能与心肌肥厚均明显改善。结论四君子汤能够通过调节肠道菌群失衡,对心肌肥厚所诱导的心力衰竭发挥一定的治疗作用。Objective To explore the healing efficacy of Sijunzi decoction on heart failure induced by myocardial hypertrophy,through regulating the dysbiosis of gut microbiota.Methods Male rats are divided into 4 groups randomly:sham group,model group,SJZT group and YSJ group.Heart failure model is established by myocardial hypertrophy induced by abdominal aortic constriction.Before and after treatment,echocardiography is performed to evaluate cardiac function.After treatment,the bacterial 16S rRNA sequencing is performed to detect gut microbiota,as well as masson staining to evaluate myocardial hypertrophy.Results After treatment,compared with model group,the dysbiosisi of gut microbiota of SJZT group is significantly improved,which manifested as dominant microbiota obviously increased and non-dominant microbiota is obviously decreased,cardiac function and myocardial hypertrophy are also obviously improved.Conclusion Sijunzi decoction can partly play a healing effect on heart failure through regulating the dysbiosis of gut microbiota.

关 键 词：心力衰竭 心肌肥厚 肠道菌群 四君子汤 

分 类 号：R285.5[医药卫生—中药学]