表观遗传学和代谢组学在中药研究中的应用  

Research progress on application of epigenetics and metabolomics in traditional Chinese medicine

作　　者：毕跃峰[1] 王云雨 张芳平 黄盈盈 白喆 程鑫涛 BI Yue-feng;WANG Yun-yu;ZHANG Fang-ping;HUANG Ying-ying;BAI Zhe;CHENG Xin-tao(College of Pharmacy,Zhengzhou University,Zhengzhou 450001,China)

机构地区：[1]郑州大学药学院,河南郑州450001

出　　处：《中草药》2020年第19期4837-4845,共9页Chinese Traditional and Herbal Drugs

基　　金：河南省自然科学基金资助项目(182300410348)。

摘　　要：中药具有多组分、多靶点、多途径的作用特色和复杂性,使得中药现代化研究任务艰巨,许多医药研究工作者为此而不懈努力。系统生物学和组学的发展,为中药与现代科学融合迎来了契机。特别是表观遗传学和代谢组学整体性、动态性、个体化以及与环境相互作用的特点与中医药作用理念相契合。主要对表观遗传学研究较为热门的DNA甲基化、组蛋白修饰、miRNA调控在中药研究中的应用,以及代谢组学在中药药效物质基础、质量控制、药效作用机制等方面的应用进行了综述,提出了二者结合创新应用在微观层面阐明中药整体作用机制及多组分、多途径、多靶点协同作用机制的思路,为中医药核心思想科学内涵研究探索新的研究模式。Traditional Chinese medicine has multi-component, multi-target, and multi-path action characteristics and complexity, which makes the task of modernizing traditional Chinese medicine arduous, and many medical researchers have made unremitting efforts to this end. The development of systems biology and omics has ushered in an opportunity for the integration of traditional Chinese medicine and modern science. In particular, the characteristics integrity, dynamics, personalization, and interaction with the environment of epigenetics and metabolomics are consistent with function concept of traditional Chinese medicine. The application of popular DNA methylation, histone modifications, mi RNA regulation of epigenetic research, and the application of metabolomics in the substance basis, quality control, pharmacodynamic action mechanism in traditional Chinese medicine research are reviewed in this paper. This paper also puts forward the idea that combining the two and innovative application can clarify the scientific connotation of the whole action mechanism of traditional Chinese medicine and the mechanism of multi-component, multi-channel, and multi-target synergistic action at the micro level, and explore a new research model for the scientific connotation of the core thought of traditional Chinese medicine.

关 键 词：表观遗传学 代谢组学 中药研究 DNA甲基化 组蛋白修饰 miRNA调控 药效物质基础 质量控制 药效作用机制 

分 类 号：R28[医药卫生—中药学]