红果樫木叶中1个新的甾体类化合物  

A new steroid from leaves of Dysoxylum binectariferum

作　　者：李兆 陈龙 赵宏伟 李兵 王晓 闫慧娇 LI Zhao;CHEN Long;ZHAO Hong-wei;LI Bing;WANG Xiao;YAN Hui-jiao(Shandong Analysis and Test Center,Qilu University of Technology(Shandong Academy of Sciences),Jinan 250014,China;School of Pharmaceutical Sciences,Qilu University of Technology(Shandong Academy of Sciences),Jinan 250014,China;Lunan Pharmaceutical Group Co.,Ltd.,Linyi 276006,China)

机构地区：[1]齐鲁工业大学(山东省科学院)山东省分析测试中心,山东济南250014 [2]齐鲁工业大学(山东省科学院)药学院,山东济南250014 [3]鲁南制药集团股份有限公司,山东临沂276006

出　　处：《中草药》2020年第19期4896-4901,共6页Chinese Traditional and Herbal Drugs

基　　金：山东省自然科学基金资助项目(ZR2017BC061);山东省科学院国际科技合作项目(2019GHPY01)。

摘　　要：目的对红果樫木Dysoxylumbinectariferum的叶部位进行化学成分研究。方法综合应用多种色谱方法进行分离纯化,根据MS及核磁共振数据进行化合物结构鉴定。结果从红果樫木叶的乙醇提取物中得到5个甾体类化合物,分别为豆甾-4(5)-烯-β,6β,22-三醇(1)、豆甾-5(6)-烯-3β,21,2-三醇(2)、2α,3β,4β-三羟基孕甾-16-酮(3)、2α,3β-二羟基-4β-乙酰氧基孕甾-16-酮(4)、2α,3β-二羟基孕甾-17(20)-烯-16-酮(5)。结论化合物1为新化合物,命名为红果豆甾A。化合物2~5均首次从红果樫木中分离得到。Objective To study the constituents of the leaves of Dysoxylum binectariferum. Methods The chemical constituents were isolated by various column chromatographic methods, and their structures were identified on the basis of MS and NMR spectral analysis. Results Five steroids were obtained and their structures were elucidated as stigmast-4(5)-en-3β,6β,22-triol(1), stigmast-5(6)-en-3β,21,22-triol(2), 2α,3β,4β-trihydroxypregnan-16-one(3), 2α,3β-dihydroxy-4β-acetoxypregnan-16-one(4) and 2α,3β-dihydroxypregnan-17(20)-en-16-one(5). Conclusion Compound 1 is identified as a new compound and named dybinstigm A. Compounds 2—5 are obtained from D. binectariferum for the first time.

关 键 词：红果樫木 甾体 红果豆甾A 豆甾-5(6)-烯-3β 21 2-三醇 2α 3β 4β-三羟基孕甾-16-酮 

分 类 号：R284.1[医药卫生—中药学]