离子色谱法测定口服电解质颗粒中阴离子的含量  

Determination of Anions in Oral Electrolyte Granules by Ion Chromatography

作　　者：张建茹 昝艳楠 丁逸梅[1,2] ZHANG Jian-ru;ZAN Yan-nan;DING Yi-mei(School of Pharmacy,Nanjing University of Technology,Nanjing 211800,China;Jiangsu Institute of Materia Medica,Nanjing 211800,China)

机构地区：[1]南京工业大学药学院,江苏南京211800 [2]江苏省药物研究所,江苏南京211800

出　　处：《海峡药学》2020年第10期63-66,共4页Strait Pharmaceutical Journal

摘　　要：目的建立离子色谱法(IC),同时测定口服电解质颗粒中3种阴离子(氯离子、磷酸根离子、柠檬酸根离子)的含量方法。方法采用Metrosep A Supp-5 column(150mm×4mm)为离子色谱柱,流动相为12.8mmol·L^-1 Na 2CO 3,等度洗脱,流速为0.7mL·min^-1,以电导检测器检测。结果在建立的色谱条件下,电解质颗粒中各阴离子(氯离子、磷酸根离子、柠檬酸根离子)之间分离良好,专属性良好,线性关系良好(r=0.9999),进样精密度、重复性及加样回收率的RSD均小于2.0%,且加样回收率在98%~103%之间。结论该方法操作简便、灵敏度高、选择性好,适用于常规样品分析。OBJECTIVE To develop an ion chromatographic method for the determination of Three anions in oral electrolytes(Chloride ion,phosphate ion,citrate ion).METHODS Ion chromatography column was performed by using Metrosep A Supp-5 column(150mm×4mm).RESULTS Good separation between the anions(Chloride ion,phosphate ion,citrate ion)in the electrolyte particles and good specificity,the linear relationship was good(r=0.9999).The RSD of injection precision,repeatability and sample recovery rate were less than 2.0%,and the sample recovery rate was between 98% and 103%.CONCLUSION The method is simple in operation,high in sensitivity and good in selectivity.

关 键 词：口服电解质 离子色谱 电导检测器 阴离子 氯离子 磷酸根离子 柠檬酸根离子 

分 类 号：R927[医药卫生—药学]