新疆哈萨克族血脂异常与心血管疾病发病风险关系的队列研究  

A cohort study on the relationship between dyslipidemia and the risk of cardiovascular disease in Kazak people in Xinjiang

作　　者：马卓 魏斌[1] 马儒林[1] 郭恒[1] 何佳[1] 木拉提[1] 胡云华[1] 郭淑霞[1] MA Zhuo;WEI Bin;MA Rulin;GUO Heng;HE Jia;MU Lati;HU Yunhua;GUO Shuxia(Department of Preventive Medicine,School of Medicine,Shihezi University,Shihezi,Xinjiang 832000,China)

机构地区：[1]石河子大学医学院预防医学系,新疆石河子832000

出　　处：《石河子大学学报（自然科学版）》2020年第5期601-606,共6页Journal of Shihezi University(Natural Science)

基　　金：国家自然科学基金项目(81560551)。

摘　　要：目的探讨新疆哈萨克族人群血脂异常与CVD发病风险的关系,为预防该人群CVD发生发展提供理论依据。方法采用双向性队列研究设计。2010年4月到2012年12月对新疆哈萨克族自治州新源县那拉提镇6个村和哈拉布拉乡18岁及以上的居民共2887人进行基线调查。将随访时间满5年的研究对象分为血脂异常组和正常组。应用Cox比例风险回归模型,分析血脂异常类型及其聚集状态与CVD发病风险的关系。结果新疆哈萨克族心血管疾病的发病率为13.84%(308/2226)。单因素分析发现高TC、TG和LDL-C血症是CVD的危险因素[HR(95%CI):2.10(1.52~2.89);1.59(1.14~2.21);2.39(1.47~3.90)],调整变量后,高TC、TG和低HDL-C血症是CVD发病的独立危险因素[HR(95%CI):1.48(1.07~2.05);1.47(1.05~2.06);1.39(1.04~1.85)]。单因素分析发现1种、2种和≥3种血脂类型异常聚集状态均是CVD的危险因素[HR(95%CI):1.59(1.23~2.06);1.80(1.17~2.75);2.62(1.39~4.96)],调整变量后发现,1种和≥3种血脂类型异常聚集状态是CVD发病的独立危险因素[HR(95%CI):1.54(1.19~2.00);2.22(1.17~4.23)],且血脂异常类型聚集越多CVD发病率越高(P<0.01)。结论新疆哈萨克族人群血脂异常能提高CVD发病的风险,并且随着血脂异常类型聚集数量越多CVD发病风险越高。Objective To investigate the relationship and intensity between dyslipidemia and the risk of CVD among Kazaks in Xinjiang,in order to provide theoretical basis for preventing the occurrence and development of CVD in this population.Methods Bidirectional cohort study design was adopted.From April 2010 to December 2012,a baseline survey was conducted on 2887 residents aged 18 or above in 6 villages of Narati town and Halabra township,Xinyuan county,Kazak autonomous prefecture,Xinjiang.The subjects who were followed up for at least 5 years were divided into the dyslipidemia group and the normal group.Cox proportional risk regression model was used to analyze the relationship between the type and aggregation of dyslipidemia and the risk of CVD.Results The incidence of cardiovascular in Kazak people in Xinjiang was 13.84%(308/2226).Univariate analysis found that high TC,TG and LDL-C were risk factors for CVD[HR(95%CI):2.10(1.52~2.89);1.59(1.14~2.21);2.39(1.47~3.90)].After adjusting for variables,high TC,TG and low HDL-C were independent risk factors for CVD[HR(95%CI):1.48(1.07~2.05);1.47(1.05~2.06);1.39(1.04~1.85)].Univariate analysis found that 1,2 and≥3 types of abnormal accumulation of blood lipid were all risk factors for CVD[HR(95%CI):1.59(1.23~2.06);1.80(1.17~2.75);2.62(1.39~4.96)].After adjusting for variables,it was found that 1 and≥3 types of abnormal accumulation of blood lipid were independent risk factors for CVD[HR(95%CI):1.54(1.19~2.00);2.22(1.17~4.23)],and the more the dyslipidemia types accumulate,the higher the incidence of CVD(P<0.01).Conclusions Dyslipidemia in Kazak population in Xinjiang can increase the risk of CVD,and the more the type of dyslipidemia accumulates,the higher the risk of CVD.

关 键 词：血脂异常 心血管疾病 队列研究 危险性 

分 类 号：R589.2[医药卫生—内分泌]