幼年皮肌炎50例临床特征及其诊治分析  

Analysis of Clinical Characteristics and Treatment of 50 Cases of Juvenile Dermatomyositis

作　　者：树叶[1] 罗鸯鸯[1] 罗勇奇[1] 汤建萍[1] 周斌[1] SHU Ye;LUO Yang-yang;LUO Yongqi(Department of dermatology,Hunan Children’s Hospital,Changsha,410007,China)

机构地区：[1]湖南省儿童医院皮肤科,湖南长沙410007

出　　处：《医学临床研究》2020年第10期1480-1482,1486,共4页Journal of Clinical Research

基　　金：湖南省科技创新计划项目(编号:2018SK50408)

摘　　要：【目的】探讨幼年皮肌炎的临床特征、治疗效果及转归。【方法】回顾性分析2011年7月至2020年1月在本院诊治的50例幼年皮肌炎临床资料。对其起病原因、临床特征、实验室检查及辅助检查、治疗方法和转归进行总结和评估。【结果】50例患儿中男女比例为1.08:1,平均年龄(8.5±4.5)岁。11例患儿发病前有上呼吸道感染史;所有患儿均有典型皮损,未见肌肉萎缩和钙质沉着,2例患儿仅有典型皮损而无肌炎症状;均未发现恶性肿瘤;最常见的内脏损害为间质性肺炎。50例患儿均采用糖皮质激素治疗,9例联合使用甲氨蝶呤。治疗效果及预后均较好。【结论】幼年皮肌炎是一种儿童少见疾病,以皮肤损害和肌无力为主要症状,其皮损具有特征性,糖皮质激素治疗有效,必要时可联合免疫抑制剂治疗。【Objective】To study the clinical characteristics,therapeutic effect and prognosis of juvenile dermatomyos itis.【Methods】Fifty cases of juvenile dermatomyositis hospitalized in Hunan children’s Hospital from July 2011 to January 2020 were analyzed retrospectively.The onset,clinical characteristics,laboratory examination*auxiliary examination,treatm ent,follow-up and prognosis were analyzed.【Results】In 50 juvenile dermatomyositis,the ratio of male to female patients was 1.08:1,with an average age of 8.5±4.5 years.Of which,11 children had a history of upper respiratory tract infection before the onset of the disease..There were 2 cases who had typical skin lesions without myositis symptoms.They both had weakened muscle strength but normal muscle tension.The most common visceral damage was interstitial pneumonia.All the children had typical skin lesions but no muscle atrophy and calcinosis.No malignant tumor was found.All 50 cases were treated with glucocorticoid;and 9 out of 50 cases received glucocorticoid combined with methotrexate.The therapeutic effect and prognosis were good.【Conclusion】Juvenile dermatomyositis is a rare disease in children,which is characterized by skin damage and muscle weakness.Muscle enzyme and electromyogram are very useful for the diagnosis of juvenile dermatomyositis.Glucocorticoid therapy is effective,if necessary,combined with immunosuppressant.

关 键 词：皮肌炎/诊断 皮肌炎/治疗 

分 类 号：R725.932.6[医药卫生—儿科]