不同剂量阿托伐他汀治疗急性前循环脑梗死临床观察  

Clinical Observation of Different Doses of Atorvastatin in the Treatment of Acute Anterior Circulation Cerebral Infarction

作　　者：张珊珊[1] 王洪超 ZHANG Shanshan;WANG Hongchao(Langfang People’s Hospital,Langfang,Hebei,China 065000)

机构地区：[1]河北省廊坊市人民医院,河北廊坊065000

出　　处：《中国药业》2020年第22期91-93,共3页China Pharmaceuticals

基　　金：河北省医学科学研究重点课题[20181464]。

摘　　要：目的探讨不同剂量阿托伐他汀治疗急性前循环脑梗死的临床疗效。方法选取医院2016年2月至2019年4月收治的急性前循环脑梗死患者120例,按住院编号分为A组、B组、C组,各40例。3组患者均予溶栓、抗凝治疗,B组、C组患者分别加服阿托伐他汀钙片20mg和40mg,3组均持续治疗2周。结果C组总有效率为85.00%,显著高于B组的75.00%和A组的50.00%(P<0.05);治疗后,C组患者的胶质纤维酸性蛋白(GFAP)、单核细胞趋化蛋白1(MCP-1)、肿瘤坏死因子-α(TNF-α)、白细胞介素6(IL-6)、白细胞介素8(IL-8)水平均显著低于A组和B组(P<0.05)。结论40mg阿托伐他汀治疗急性前循环脑梗死效果较好,且可显著降低患者的GFAP,TNF-α,MCP-1,IL-6,IL-8水平。Objective To investigate the clinical efficacy of different doses of atorvastatin in the treatment of acute anterior circulation cerebral infarction.Methods Totally 120 patients with acute anterior circulation cerebral infarction admitted to our hospital from February 2016 to April 2019 were selected and divided into group A,group B and group C according to the hospitalization numbers,40 cases in each group.The patients in the three groups were treated with thrombolytic and anticoagulant.The patients in group B and group C were given Atorvastatin Calcium Tablets 20 mg,40 mg,respectively.The three groups were continuously treated for 2 weeks.Results The total effective rate of group C was 85.00%,which was significantly higher than 75.00%of group B and 50.00%of group A(P<0.05).After treatment,the levels of glial fibrillary acidic protein(GFAP),monocyte chemoattractant protein-1(MCP-1),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and interleukin-8(IL-8)in group C were significantly lower than those in group A and group B(P<0.05).Conclusion 40 mg atorvastatin is effective in the treatment of acute anterior circulation cerebral infarction,and it can significantly reduce the levels of GFAP,TNF-α,MCP-1,IL-6 and IL-8.

关 键 词：阿托伐他汀 急性 前循环脑梗死 单核细胞趋化蛋白1 胶质纤维酸性蛋白 炎性因子 临床疗效 

分 类 号：R969.4[医药卫生—药理学] R972+.6[医药卫生—药学]