阻塞性睡眠呼吸暂停诱发肠道菌群紊乱与动脉粥样硬化关系的进展  

Progress in research on the relationship between gut dysbiosis induced by obstructive sleep apnea and atherosclerosis

作　　者：吴慧 姜秀峰 WU Hui;JIANG Xiufeng(Department of Respiratory,Wuxi Fifth People′s Hospital,Wuxi,Jiangsu 214023,China;不详)

机构地区：[1]无锡市第五人民医院,江苏无锡214023

出　　处：《中国微生态学杂志》2020年第10期1233-1237,共5页Chinese Journal of Microecology

摘　　要：阻塞性睡眠呼吸暂停是一种常见的呼吸疾病,其与动脉粥样硬化的发生发展密切相关。近年来,随着对肠道菌群的深入探索,越来越多的研究发现肠道菌群与阻塞性睡眠呼吸暂停和动脉粥样硬化均密切相关,并且可能在二者之间起桥梁作用,其主要表现在阻塞性睡眠呼吸暂停可诱发肠道菌群失调、肠道屏障受损和肠道代谢产物改变,而这些改变可能参与了阻塞性睡眠呼吸暂停促进动脉粥样硬化发生发展的过程。本文就这些研究作一综述,以期为探讨阻塞性睡眠呼吸暂停致动脉粥样硬化的发生机制和治疗提供新的思路。Obstructive sleep apnea is a common respiratory disease that is closely related to the development of?atherosclerosis.In recent years,with the in-depth exploration of gut microbiota,more and more studies have found that gut microbiota is closely related to obstructive sleep apnea and atherosclerosis,and may play a bridge role between them.It mainly embodies as that obstructive sleep apnea induces gut dysbiosis,intestinal barrier damage,and intestinal metabolite changes,and these intestinal changes may be involved in the process of development of atherosclerosis promoted by obstructive sleep apnea.This article reviews these studies,in order to provide new ideas for research on the mechanism and treatment of atherosclerosis caused by obstructive sleep apnea.

关 键 词：阻塞性睡眠呼吸暂停 动脉粥样硬化 肠道菌群 

分 类 号：R56[医药卫生—呼吸系统]