免疫刺激剂CpG ODN在家禽疾病防控中的研究进展  

Research Progress of Immune Stimulant CpG ODN in Poultry Diseases Control

作　　者：苏胖 武力[1,2] 李美娣 刘汉清 王甜 SU Pang;WU Li;LI Meidi;LIU Hanqing;WANG Tian(College of Veterinary Medicine,South China Agricultural University,Guangzhou,Guangdong 510642;Guangdong Huanong Hi-Tech BiologicalPharmaceutical Co.,Ltd.,Guangzhou,Guangdong 510642;Meizhou Polytechnic,Meizhou,Guangdong 514011)

机构地区：[1]华南农业大学兽医学院,广东广州510642 [2]广东华农高科生物药业有限公司,广东广州510642 [3]梅州职业技术学院,广东梅州514011

出　　处：《中国家禽》2020年第10期94-99,共6页China Poultry

摘　　要：CpG ODN是含一个或多个非甲基化CpG基序的寡聚脱氧核苷酸,根据其结构及生物学活性的不同,分为A、B、C、P四种类型,目前在家禽疾病防控方面的研究主要以B型CpG ODN为主,CpG ODN通过与鸡TLR-21受体结合发挥其免疫刺激活性,可用于防控鸡常见细菌性感染、病毒性感染以及球虫感染等。文章从CpG ODN的分类、作用机制、家禽疾病防控等方面进行阐述,为CpG ODN在家禽生产中的应用提供参考。CpG ODN is an oligodeoxynucleotides containing one or more unmethylated CpG motifs. According to the different structure and biological activity, there are four types, which are A, B, C and P. At present, the study for poultry diseases control is mainly based on B-type CpG ODN. CpG ODN exerts its immunostimulatory activity by combining with chicken TLR-21 receptors and can be used for bacterial infection, viral infection and coccidia infection.This paper mainly discussed the classification, mechanism, control of poultry diseases, and provided a reference for application of CpG ODN in poultry production.

关 键 词：鸡 CpG ODN TLR-21 免疫调节机制 家禽疾病防控 

分 类 号：S852.4[农业科学—基础兽医学]