血清半胱氨酸蛋白酶抑制剂C、血清肌酐、24h肌酐清除率在儿童慢性肾脏病分期诊断中的应用价值  

Application value of serum cystatin C,serum creatinine and 24 h creatinine clearance rate in staging diagnosis of chronic kidney disease children

作　　者：王宁[1] 黄燕萍[1] Wang Ning;Huang Yanping(Department of Pediatrics,First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China)

机构地区：[1]西安交通大学第一附属医院儿科,西安710061

出　　处：《中国医学前沿杂志（电子版）》2020年第11期112-115,共4页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

摘　　要：目的探讨血清半胱氨酸蛋白酶抑制剂C(cystatin C,Cys C)、血清肌酐(serum creatinine,Scr)、24 h肌酐清除率(creatinine clearance rate,Ccr)在儿童慢性肾脏病(chronic kidney disease,CKD)分期诊断中的应用价值。方法将2016年10月至2018年10月西安交通大学第一附属医院收治的96例CKD患儿纳入研究组,检测其血清Cys C和Scr水平,并计算24 h Ccr和估算的肾小球滤过率(estimated glomerular filtration rate,eGFR),以eGFR结果为依据,将96例患儿进行CKD分期。将该院同期30例体检健康儿童纳入对照组,比较研究组不同CKD分期患儿与对照组儿童Cys C、Scr水平和24 h Ccr之间的差异,并分析儿童CKD分期与Cys C、Scr水平和24 h Ccr的相关性。结果研究组不同CKD分期患儿Cys C水平均显著高于对照组(均P<0.05),且Cys C水平随着CKD分期的增高而逐渐升高(均P<0.05);CKD分期Ⅱ~Ⅴ期患儿Scr水平均显著高于对照组(均P<0.05),且Scr水平随着CKD分期的增高而逐渐升高(均P<0.05);CKD分期Ⅱ~Ⅴ期患儿24 h Ccr均显著低于对照组(均P<0.05),且24 h Ccr随着CKD分期的增高而逐渐降低(均P<0.05)。CKD分期与Cys C、Scr水平均呈显著正相关(均P<0.05),与24 h Ccr均呈显著负相关(均P<0.05),且随着CKD分期的增高,此种相关性逐渐增强。结论Cys C、Scr、24 h Ccr均能为儿童CKD的分期诊断提供可靠参考。Objective To explore the application value of serum cystatin C(Cys C),serum creatinine(Scr),24 h creatinine clearance rate(Ccr)in the staging diagnosis of chronic kidney disease(CKD)children.Method Ninety-six children with CKD admitted to the First Affiliated Hospital of Xi'an Jiaotong University from October 2016 to October 2018 were included in study group,the serum Cys C and Scr levels were detected,and the 24 h Ccr and estimated glomerular filtration rate(eGFR)were calculated,based on the eGFR results,96 children were staged by CKD.Thirty cases healthy children during the same period in this hospital were included in control group,the levels of Cys C,Scr and 24 h Ccr in children with different CKD staging were compared with those in control group,and the correlation of CKD staging with Cys C,Scr and 24 h Ccr were analyzed.Result The level of Cys C in children with different CKD staging in study group was significantly higher than that in control group(all P<0.05),and the Cys C level increased with the increase of CKD staging(all P<0.05);the Scr levels of children with CKD stagingⅡ~Ⅴwere significantly higher than that of control group(all P<0.05),and the Scr level was gradually increased with the increase of CKD staging(all P<0.05);the 24 h Ccr of children with CKD stagingⅡ~Ⅴwere significantly lower than that of control group(all P<0.05),and the 24 h Ccr gradually decreased with the increase of CKD staging(all P<0.05).CKD staging was significantly positively correlated with the level of Cys C and Scr(all P<0.05),and negatively correlated with 24 h Ccr(all P<0.05).Conclusion Cys C,Scr and 24 h Ccr can provide reliable references for staging diagnosis of CKD in children.

关 键 词：慢性肾脏病 儿童 半胱氨酸蛋白酶抑制剂C 血清肌酐 肌酐清除率 

分 类 号：R726.9[医药卫生—儿科]