益气活血补肾法治疗腰椎间盘突出症及对疼痛介质、SOD水平影响研究  

Effect of Tonifying Qi and Activating Blood Circulation and Tonifying Kidney Method on Pain mediators and SOD in Treatment of Lumbar Intervertebral Disc Herniation

作　　者：葛向荣 林继红 张金玲 齐然 马红霞 GE Xiangrong;LIN Jihong;ZHANG Jinling;QI Ran;MA Hongxia(Hip Department Four,Luoyang Orthopaedic Hospital(Henan Orthopaedic Hospital),Luoyang 471002,Henan,China)

机构地区：[1]河南省洛阳正骨医院(河南省骨科医院)颈腰痛科,河南洛阳471002

出　　处：《中华中医药学刊》2020年第10期98-100,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：国家中医药管理局中医药科学技术研究专项(2017ZX953)。

摘　　要：目的研究益气活血补肾法治疗腰椎间盘突出症对疼痛介质、超氧化物歧化酶(SOD)水平影响。方法选取医院2015年3月—2017年3月收治的腰椎间盘突出症患者92例,根据治疗方法不同分为两组。对照组给予常规对症治疗,观察组给予益气活血补肾法治疗,分析两组患者治疗后的临床疗效。结果观察组总有效率为93.48%(43/46),对照组为78.26%(36/46),观察组患者总有效率高于对照组(P<0.05)。两组治疗前前列腺素E2(PGE2)、5-羟色胺(5-HT)、SOD水平组间比较,差异不具有统计学意义(P>0.05)。观察组治疗后PGE2、5-HT水平低于对照组,SOD水平高于对照组(P<0.05)。两组治疗前视觉模拟评分(VAS)、日本骨科协会腰痛评分(JOA)组间比较,差异不具有统计学意义(P>0.05)。观察组治疗后VAS评分低于对照组,JOA评分高于对照组(P<0.05)。观察组不良反应率6.52%(3/46)与对照组8.70%(4/46)比较,差异不具有统计学意义(P>0.05)。结论益气活血补肾法治疗腰椎间盘突出可减轻患者疼痛,改善腰椎活动功能,调节疼痛介质、SOD的表达水平,且安全性高。Objective The effects of tonifying Qi and activating blood circulation and tonifying Kidney method on the pain mediators and superoxide dismutase(SOD)in the treatment of lumbar disc herniation were studied.Methods Ninety-two cases of lumbar disc herniation were selected from April 2015 to October 2018.According to the treatment methods,the patients were divided into two groups.The patients in the control group were treated with routine symptomatic therapy and the observation group were treated with the method of tonifying Qi and activating blood circulation and tonifying kidney.The clinical effects of the two groups were analyzed.Results The total effective rate was 93.48%(43/46)in the observation group and 78.26%(36/46)in the control group,and the total effective rate in the observation group was higher than that in the control group(P<0.05).Before treatment,the levels of prostaglandin E2(PGE2)and 5-hydroxytryptamine(5-HT)and SOD in the two groups were not statistically significant(P>0.05).After treatment,the levels of PGE2 and 5-HT in the observation group were lower than those in the control group,while the level of SOD in the observation group was higher than that in the control group(P<0.05).The difference was not statistically significant(P>0.05).The scores of VAS and JOA in the observation group were lower than those in the control group after treatment(P<0.05).There was no significant difference in adverse reaction rate between the observation group 6.52%(3/46)and the control group 8.70%(4/46)(P>0.05).Conclusion The method of tonifying Qi and activating blood circulation and tonifying kidney can relieve the pain of patients with lumbar disc herniation,improve the function of lumbar spine activity,regulate the levels of pain mediators and SOD,and has high safety.

关 键 词：益气活血补肾法 腰椎间盘突出症 疼痛介质 超氧化物歧化酶 安全性 

分 类 号：R269.815.3[医药卫生—中西医结合]