HE4水平与卵巢癌病理分型的关系及其临床价值探讨  

The correlation between HE4 level and pathological classification of ovarian cancer and its clinical value

作　　者：章汪慧 庄薇 张良权[1] 许成琼 陈露露 马波 ZHANG Wanghui;ZHUANG Wei;ZHANG Liangquan;XU Chengqiong;CHEN Lulu;MA Bo(Department of Obstetrics and Gynecology,The 901 Hospital of the Joint Logistic Support Force of Chinese People's Liberation Army,Hefei 230000,Anhui,China;Eugenics Genetics Laboratory,Qinhuangdao Maternal and Child Health Care Hospital,Qinhuangdao 066000,Hebei,China)

机构地区：[1]中国人民解放军联勤保障部队第九○一医院妇产科,合肥230000 [2]秦皇岛市妇幼保健院优生遗传实验室,河北秦皇岛066000

出　　处：《中国性科学》2020年第10期34-38,共5页Chinese Journal of Human Sexuality

摘　　要：目的探讨人附睾蛋白4(HE4)水平与卵巢癌病理分型的关系及其临床价值。方法选取2016年1月至2019年1月中国人民解放军联勤保障部队第九○一医院诊治并最终完成随访的168例拟行手术治疗的卵巢癌患者作为研究对象。术前均检测血清HE4和癌抗原125(CA125),观察术后不同病理分型患者的血清HE4、CA125水平,分析HE4和CA125预测淋巴结转移的效能,比较化疗期间血清HE4水平的变化,比较高HE4组与低HE4组中位的累积复发率。结果卵巢上皮癌患者血清HE4、CA125水平明显高于非上皮癌患者,差异具有统计学意义(P<0.05);不同病理类型的卵巢上皮癌患者血清HE4水平间差异具有统计学意义(P<0.05);HE4和CA125预测卵巢癌患者淋巴结转移的AUC分别为0.855、0.630,差异具有统计学意义(P<0.05);完全缓解组第1次、第2次、第3次和第4次化疗后血清HE4中位水平均明显低于非完全缓解组,差异具有统计学意义(P<0.05);高HE4组2年累积复发率为31.47%,明显高于低HE4组的18.53%,差异具有统计学意义(P<0.05)。结论卵巢癌患者血清HE4水平与病理分型有关,其预测淋巴结转移的效能较好,对于判断初治效果、评估预后均具有一定作用,值得进一步研究。Objective To investigate the relationship between the level of human epididymal protein 4(HE4)and the pathological classification of ovarian cancer and its clinical value.Methods From January 2016 to January 2019,168 patients with ovarian cancer treated in the 901 Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army were selected as the research objects.Serum HE4 and cancer antigen 125(CA125)were detected before operation.The serum levels of HE4 and CA125 in patients with different pathological types after operation were observed.The efficacy of HE4 and CA125 in predicting lymph node metastasis was analyzed.The changes in serum HE4 level during chemotherapy and the median cumulative recurrence rate of high HE4 group and low HE4 group were compared.Results The serum levels of HE4 and CA125 in patients with epithelial ovarian cancer were significantly higher than those in patients with non-epithelial cancer,with statistically significant differences(P<0.05).There were statistically significant differences in the serum HE4 levels of patients with different pathological types of epithelial ovarian cancer(P<0.05).The AUC scores of HE4 and CA125 in predicting lymph node metastasis of ovarian cancer patients was significantly higher than that of non-epithelial cancer patients,with statistically significant differences(P<0.05).The median level of serum HE4 after the first,second,third and fourth chemotherapy in complete remission group was significantly lower than that in the non-complete remission group accordingly,with statistically significant differences(P<0.05).The 2-year cumulative recurrence rate of high HE4 group(31.47%)was significantly higher than that of low HE4 group(18.53%),with statistically significant differences(P<0.05).Conclusions Serum HE4 level in patients with ovarian cancer is related to the pathological classification,which has a good predictive effect on lymph node metastasis,and has a certain role in judging the initial treatment effect and evaluating the prognosi

关 键 词：卵巢癌 病理分型 人附睾蛋白4 癌抗原125 淋巴结转移 复发 

分 类 号：R711[医药卫生—妇产科学]