局部制霉菌素治疗口腔黏膜损伤艾滋病患者的效果观察  

Effect of local nystatin treatment on AIDS patients with oral mucosal damage

作　　者：张静 王丽君 张兆林[1] 李雪[1] 张媛媛 周新 ZHANG Jing;WANG Lijun;ZHANG Zhaolin;LI Xue;ZHANG Yuanyuan;ZHOU Xin(Department of Special Outpatient,Cangzhou Infectious Disease Hospital,Cangzhou 061001,Hebei,China;Department of Teaching and Research,Cangzhou medical college,Cangzhou 061001,Hebei,China;Department of Gynecology,Cangzhou Women and Childen's Health Hospital,Cangzhou 061001,Hebei,China)

机构地区：[1]沧州市传染病医院特需门诊,河北沧州061001 [2]沧州市医学高等专科学校教研部,河北沧州061001 [3]沧州市妇幼保健院妇科,河北沧州061001

出　　处：《中国性科学》2020年第10期132-135,共4页Chinese Journal of Human Sexuality

基　　金：沧州市科学技术研究与发展指导计划项目(172302026)。

摘　　要：目的探讨局部制霉菌素治疗艾滋病患者口腔黏膜损伤疗效。方法选取2017年12月至2018年12月沧州市传染病医院诊治的82例口腔黏膜损伤的艾滋病患者作为研究对象。按治疗方式不同分成对照组(实施洗必泰漱口液、生理盐水漱口,碳酸氢钠液治疗,n=41)和观察组(在对照组基础上采用制霉菌素治疗,n=41)。观察两组患者临床治疗效果以及唾液内β防御素(hBD)-2、hBD-3、白细胞介素(IL)-10、干扰素-γ(IFN-γ)和IL-6及肿瘤坏死因子-α(TNF-α)含量变化。结果观察组患者和对照组患者治疗总有效率分别为92.68%、78.05%,差异具有统计学意义(χ2=6.172,P=0.008);治疗后观察组患者唾液内IFN-γ、IL-6及TNF-α含量分别为(70.10±6.45)ng/L、(24.68±5.10)ng/L及(42.19±4.55)ng/L,低于对照组患者的(77.19±6.37)ng/L、(35.61±5.43)ng/L及(49.34±4.28)ng/L,差异具有统计学意义(t=8.654、16.673、8.552,P=0.001、0.001、0.001);治疗后观察组患者唾液内hBD-2、hBD-3含量分别为(2.29±1.06)ng/mL、(130.51±15.27)pg/mL,低于对照组患者的(3.87±1.14)ng/mL、(158.74±15.60)pg/mL,差异具有统计学意义(t=3.146、9.760,P=0.006、0.001)。结论艾滋病口腔黏膜损伤患者采用局部制霉菌素治疗,可有效提升临床疗效,降低口腔内炎性反应程度。Objective To analyze the effect of local nystatin on oral mucosal damage in AIDS patients.Methods From December 2017 to December 2018,82 AIDS patients with oral mucosal damage treated in Cangzhou Infectious Disease Hospital of Hebei province were selected as research objects.According to different treatment methods,the patients were divided into control group(administered with chlorhexidine mouthwash,normal saline mouthwash,sodium bicarbonate solution,n=41)and observation group(treated with nystatin on the basis of control group,n=41).The clinical treatment effect,the content of beta defense-2(HBD-2),HBD-3,interleukin-10(IL-10),γ-interferon(IFN-γ),IL-6 and TNF-αin saliva were observed in the two groups.Results After treatment,IFN-γ,IL-6 and TNF-αin the observation group were(70.10±6.45)ng/L,(24.68±5.10)ng/L and(42.19±4.55)ng/L respectively,which were lower than those in the control group[(77.19±6.37)ng/L,(35.61±5.43)ng/L and(49.34±4.28)ng/L],with statistically significant differences(t=8.654,16.673,8.552,P=0.001,0.001,and 0.001).After treatment,HBD-2 and HBD-3 in the saliva of patients in the observation group were(2.29±1.06)ng/mL and(130.51±15.27)pg/mL respectively,which were lower than those in the control group(3.87±1.14)ng/mL and(158.74±15.60)pg/mL,and the differences were statistically significant(t=3.146,9.760,P=0.006,0.001).Conclusions Treatment with local nystatin can effectively improve the clinical efficacy and reduce the degree of oral inflammatory response in AIDS patients with oral mucosal damage.

关 键 词：艾滋病 口腔黏膜损伤 制霉菌素 炎性因子 

分 类 号：R759[医药卫生—皮肤病学与性病学]