代谢组学在心肌梗死中的应用概述  

An overview of the application of metabolomics in myocardial infarction

作　　者：张芳妮 房绍红[1] 孙博[1] Zhang Fangni;Fang Shaohong;Sun Bo(Department of Neurobiology of Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学神经生物教研室,150081

出　　处：《国际免疫学杂志》2020年第5期513-518,共6页International Journal of Immunology

基　　金：国家自然科学面上基金(81870353)国家重点研发计划资助项目(2016YFC1301100)。

摘　　要：心肌梗死是一种常见的心血管疾病,具有很高的致死率。早已有研究证明心肌梗死等心血管疾病与代谢异常相关。代谢组学是继基因组学,转录组学和蛋白组学之后发展的一门检测机体内代谢物变化的新兴技术,可用来发现疾病的潜在标志物,揭示疾病的病理机制和发现药物作用靶点等以应用到临床的预防和诊疗中。近年来代谢组学已被应用在心肌梗死的研究领域,现就代谢组学在心肌梗死中的应用进行综述,以期为预防和诊治心肌梗死提供更多思路。Myocardial infarction is a common cardiovascular disease with high mortality.Previous studies have proved that cardiovascular diseases including myocardial infarction are related to metabolic abnormalities.Metabolomics is an emerging technology developed after genomics,transcriptomics and proteomics to detect the changes of metabolites in the body,which helps discovering the potential markers of diseases and finding the drug target for clinical prevention and treatment.Metabolomics has been used in the study of myocardial infarction in recent years.This paper reviews the application of metabolomics in myocardial infarction.

关 键 词：心血管疾病 心肌梗死 代谢组学 

分 类 号：R542.22[医药卫生—心血管疾病]