microRNAs在自身免疫性疾病中的研究进展  

Research progress of microRNAs in autoimmune diseases

作　　者：孟燕婷 孙博[1] 李呼伦[1] Meng Yanting;Sun Bo;Li Hulun(Department of Neurobiology,Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学神经生物教研室,150081

出　　处：《国际免疫学杂志》2020年第5期585-591,共7页International Journal of Immunology

摘　　要：microRNA(miRNAs)是一种长约21~25个核苷酸的非编码RNA分子,通过与其靶基因mRNA的3′非编码区结合调控基因的表达,从而控制细胞生长、增殖、分化、衰老、凋亡、以及代谢、炎症和免疫反应等多种生理、病理过程。据报道,许多miRNA在自身免疫性疾病中差异表达,并且可能在调节免疫应答和自身免疫中发挥关键作用。此篇综述阐述了目前多发性硬化、系统性红斑狼疮、炎症性肠病等自身免疫性疾病中miRNAs的研究进展。microRNAs(miRNAs)are non-coding RNA molecules of about 21~25 nucleotides.They regulate gene expression by binding to the 3′non-coding region of their target gene mRNA,thereby controlling a variety of physiological and pathological processes such as cell growth,proliferation,differentiation,aging,apoptosis,and metabolism,inflammation,immune response.Many miRNAs have been reported to be differentially expressed in autoimmune diseases and may play a key role in regulating immune responses and autoimmunity.This review summarizes the research progress of miRNAs in autoimmune diseases such as multiple sclerosis,systemic lupus erythematosus and inflammatory bowel disease.

关 键 词：MIRNAS 免疫系统 自身免疫性疾病 

分 类 号：R593.2[医药卫生—内科学]