色氨酸及其代谢产物对肠粘膜免疫屏障的调节作用  

Regulatory of tryptophan and its metabolites on intestinal mucosa immune barrier

作　　者：宋琦 王琦[2] Song Qi;Wang Qi(Second Clinical Medical College of Shanxi Medical University,Taiyuan 030001,China;Department of Gastroenterology,the Second Hospital of Shanxi Medical University,Taiyuan 030000,China)

机构地区：[1]山西医科大学第二临床医学院,太原030000 [2]山西医科大学第二医院消化科,太原030000

出　　处：《国际免疫学杂志》2020年第5期592-596,共5页International Journal of Immunology

摘　　要：作为一种必需氨基酸,色氨酸(tryptophan,Trp)通过血清素(5-羟色胺)、犬尿氨酸(kynurenine,Kyn)的内源性代谢途径和微生物代谢途径产生5-羟色胺、烟酸、CO2、犬尿喹啉和吲哚衍生物等代谢产物。Trp及其代谢产物在机体内可通过激活芳香烃受体(aromatic hydrocarbon receptor,AhR)、孕烷X受体(progesterone X receptor,PXR),诱导胰高血糖素样肽-1(glucagon like peptide-1,GLP-1)释放,改善肠道抗氧化能力及线粒体功能,促进5-HT释放等机制参与调节机体健康。这里通过阐述Trp、Trp代谢过程以及Trp代谢物的作用机制,探讨Trp及其代谢产物对肠粘膜免疫屏障的调节作用。As an essential amino acid,tryptophan(Trp)produces 5-hydroxytryptamine,niacin,CO2,quinoline and indole derivatives through serotonin(5-HT),kynurenine(Kyn)and microbial metabolic pathway.Trp and its metabolites can regulate body health by activating aromatic hydrocarbon receptor(AhR),progesterone X receptor(PXR),inducing the release of glucagon like peptide-1(GLP-1),improving intestinal antioxidant capacity and mitochondrial function,and promoting the release of 5-HT.In this review,we discussed the regulatory effect of Trp and its metabolites on intestinal mucosal immune barrier by elaborating the Trp,Trp metabolism and the mechanism of Trp metabolites.

关 键 词：色氨酸 芳香烃受体 孕烷X受体 肠道免疫屏障 

分 类 号：R392[医药卫生—免疫学]