中国人群输血相关急性肺损伤58例文献回顾性分析  

Retrospective analysis of 58 cases of transfusion-related acute lung injury in Chinese population

作　　者：刘晓敏[1] 江颖[1] 刘俊婷 张雷英 庄远[1] 汪德清[1] 李尊严[2] 于洋[1] LIU Xiaomin;JIANGYing;LIU Junting;ZHANG Leiying;ZHUANG Yuan;WANG Deqing;LI Zunyan;YU Yang(Medcine,the First Medical Center,Chinese PLA General Hospital,Beijing 100853,China;Department of Blond Transfusion,Affiliated Hospital of Beihua University)

机构地区：[1]解放军总医院第一医学中心,输血医学科,北京100853 [2]北华大学附属医院输血科

出　　处：《中国输血杂志》2020年第8期780-783,共4页Chinese Journal of Blood Transfusion

基　　金：吉林省卫生与健康科技能力提升计划组(2018J097);解放军总医院医疗大数据研发项目(2018MBD-025)

摘　　要：目的分析中国人群输血相关急性肺损伤的发病特点、临床表现及转归,为进一步有效预防其发生提供参考。方法检索Medline、PubMed、中国知网、中国生物医学数据库、维普数据库和万方数据库发表的中国人群输血相关急性肺损伤的个案报道文献并进行回顾性分析。结果研究共纳入41篇案例报道,58个病例,其中男性40例,女性18例,平均年龄为(37.7±20.4)岁,输注的血液成分包括全血、红细胞、血浆、血小板、冷沉淀和丙种球蛋白。58例病例的主要临床症状均为呼吸困难、低氧血症、心率快(93.1%,54/58)、低血压(46.6%,27/58)。58例病例中65.5%(38/58)好转,34.5%(20/58)死亡,经Logistic回归分析显示,年龄和误诊误治是影响患者预后的危险因素。结论目前我国对于TRALI的诊断和管理尚不完善,采取多方位积极的管理措施才能有效减少TRALI的发生率和死亡率。Objective To analyze the characteristics,clinical manifestations and outcome of transfusion-related acute lung injury(TRALI) in the Chinese population, and to provide references for further effective prevention of its occurrence. Methods The literature of TRALI in Chinese population published by Medline, PubMed, CNKI, CBM, VIP Database and Wanfang Database were searched and analyzed retrospectively. Results This study reviewed a total of 41 publications involving 58 individuals consisting of 40 males and 18 females, with an average age of(37.7±20.4) years old. Whole blood, red blood cells, plasma, platelets, cryoprecipitate and gamma globulin were the mainly blood components transfused for TRALI recipients. 93.1%(54/58) of 58 individuals complained symptoms as dyspnea, hypoxemia and rapid heart rate, and 46.6%(27/58)as hypotension. Of the 58 cases, 65.5%(38/58) improved and 34.5%(20/58) died. Logistic regression analysis showed that age and misdiagnosis were risk factors affecting the prognosis of patients. Conclusion At present, the diagnosis and management of TRALI in China are still evolving. The incidence and mortality of TRALI could be reduced by adopting multi-perspective and active management measures.

关 键 词：中国人群 输血相关急性肺损伤 文献分析 

分 类 号：R373.1[医药卫生—病原生物学] R563[医药卫生—基础医学]