基于大标本量基础分析北京地区献血人群HTLV-Ⅰ/Ⅱ感染情况  

Seroprevalence of HTLV-Ⅰ/Ⅱ among voluntary blood donors in Beijing based on large sample

作　　者：张婧[1] 王瑞[1] 胡京辉[1] 刘彦[1] 吴硕[1] 冷婵[1] 高楠[1] 王露楠[2] 葛红卫[1] ZHANG Jing;WANG Rui;HU Jinghui;LIU Yan;WU Shuo;LENG Chan;GAO Nan;WANG Lunan;GE Hongwei(Beijing Red Cross Blood Center,National Center for Clinial Laboratories;Beijing Hospital,National Center for Gerontology)

机构地区：[1]北京市红十字血液中心,北京100083 [2]北京医院国家老年医学研究中心卫生部临床检验中心

出　　处：《中国输血杂志》2020年第8期814-817,共4页Chinese Journal of Blood Transfusion

摘　　要：目的对北京地区献血人群人类T淋巴细胞白血病病毒(HTLV,human T-cell lymphotropicvirus)Ⅰ/Ⅱ抗体阳性率进行基线调查,为科学制定抗-HTLV血液筛查策略提供数据依据。方法 1)采用双抗原夹心酶联免疫吸附试验(ELISA)对137 833份献血者标本进行HTLV-Ⅰ/Ⅱ抗体检测,并通过免疫印迹试验(WB)确认标本HTLV结果。2)文献检索获取其他地区献血人群HTLV感染情况数据,与本次调查结果进行比较,评估北京地区献血人群情况。结果 1)137 833份标本中ELISA初筛反应性标本共26例,经补充试验确认真阳性2例、不确定2例。北京地区献血人群中HTLV-Ⅰ/Ⅱ抗体初筛阳性率为0.019%(26/137 833),确认阳性率为0.0015%(2/137 833)。2例HTLV阳性献血者均为外地户籍,均来自于HTLV低流行地区。2)北京地区献血人群中HTLV-Ⅰ/Ⅱ抗体的确认阳性率明显低于福建、广东和浙江地区,但与河北、天津、上海、重庆和深圳无差异。结论北京地区献血人群中存在HTLV感染者,但属于HTLV低流行地区。Objective To investigate the prevalence of human T-cell lymphotropic virus Ⅰ/Ⅱ(HTLV-Ⅰ/Ⅱ)infection in voluntary blood donors in Beijing based on the basic survey,so as to provide data support for making scientific protocols for HTLV blood screening. Methods A total of 137 833 donations were initially subjected to anti-HTLV-Ⅰ/Ⅱ antibodies screening by ELISA, and ELISA reactive samples were further confirmed by Western Blot(WB). The status of HTLV-Ⅰ/Ⅱ infection in Beijing blood donors was evaluated through the comparison with other areas available at literature retrieval.Results 26 out of 137 833 samples(0.019%) were serologically reactive for HTLV-Ⅰ/Ⅱ. Confirmatory WB showed that 2(0.0015%) were HTLV-Ⅰ/Ⅱ positive and 2 inderterminate. Two HTLV-Ⅰ/Ⅱ positive blood donors were not natives in Beijing and migrated from low-endemic areas. The prevalence of HTLV-Ⅰ/Ⅱinfection in Beijing blood donors was significantly lower than that of coastal provinces such as Fujian, Guangdong and Zhejiang, and similar to Hebei, Tianjin, Shanghai, Chongqing, and Shenzhen areas. Conclusion Voluntary blood donors in Beijing is a low-endemic population for HTLV infection, though HTLV-Ⅰ/Ⅱ positive blood donors had been detected.

关 键 词：人类T淋巴细胞白血病病毒 献血人群 北京地区 

分 类 号：R446.62[医药卫生—诊断学]