聚天冬氨酸苄酯改性纳米羟基磷灰石的制备  

Preparation of nano-HA modified by PBLA

作　　者：徐敏 熊兵[1] 舒扬[1] 郭建业 帅文苑 黄萍 Xu Min;Xiong Bing;Shu Yang;Guo Jianye;Shuai Wenyuan;Huang Ping(Department of Biochemistry,Nanchang University College of Science and Technology,Nanchang 330029;Nanchang University,Nanchang 330031)

机构地区：[1]南昌大学科学技术学院生物化学系,南昌330029 [2]南昌大学,南昌330031

出　　处：《化工新型材料》2020年第10期282-285,共4页New Chemical Materials

基　　金：江西省教育厅科学技术研究项目(GJJ161522)和(GJJ191564);南昌大学科学技术学院科研基金(2013-ZR-06)。

摘　　要：描述了一种羟基磷灰石(HA)表面改性的制备方法,它是通过L-天冬氨酸-β-苄酯-N-羧酸酐开环聚合的方法制得。首先,将HA和硅烷偶联剂KH-550反应得到表面含有活性氨基的改性羟基磷灰石(HAAPS)。其次,HAAPS引发L-天冬氨酸-β-苄酯-N-羧酸酐(BLA-NCA)开环聚合得到表面接枝聚天冬氨酸苄酯(PBLA)的羟基磷灰石(PBLA-g-HA),实现了HA表面由亲水性向疏水性的转变,合成结果通过红外光谱(FT-IR)与热重(TG)表征。FT-IR和TG结果均证实HA被成功接枝,通过控制不同的反应时间和比例,羟基磷灰石表面的PBLA接枝量为28.32%~60.48%。分散性实验证实经过PBLA表面改性的HA可显著地增加HA表面的疏水性和防止纳米粒子HA的聚集。A preparation method of hydroxyapatite(HA)surface modification was described,PBLA-g-HA was prepared by ring opening polymerization of L-aspartic acid-β-benzyl ester-N-carboxylic anhydride.First,HA was reacted with silane coupling agent KH550 to obtain modified hydroxyapatite(HAAPS)with active amino groups on its surface.Secondly,HAAPS initiated the ring opening polymerization of L-aspartic acid-β-benzyl ester-N-carboxylic anhydride(BLA-NCA)to obtain hydroxyapatite(PBLA-g-HA)grafted with polyaspartic acid benzyl ester(PBLA).The surface of HA was changed from hydrophilic to hydrophobic.The results were characterized by FT-IR,TGA.FT-IR and TGA showed that HA was successfully grafted.By controlling the reaction time and ratio,the grafting amount of PBLA on the surface of HA was 28.32%~60.48%.The dispersity experiment confirmed that HA modified by PBLA could significantly increase the hydrophobicity of HA surface,and prevented the aggregation of HA nanoparticles.

关 键 词：表面改性 开环聚合 羟基磷灰石 聚氨基酸 

分 类 号：TB383[一般工业技术—材料科学与工程]