国人脊柱与骨盆^99mTc-MDP定量SPECT/CT标准化摄取值的正常分布特点  

The normal distribution characteristics of standardized uptake value of spine and pelvis with 99mTc-MDP quantitative SPECT/CT in Chinese people

作　　者：侯晓广 刘国兵 孙登琴 顾宇参 HOU Xiao-guang;LIU Guo-bing;SUN Deng-qin;GU Yu-shen(Department of Nuclear Medicine,Zhongshan Hospital,Fudan University,Shanghai 200032,China;Insititute of Nuclear Medicine,Fudan University,Shanghai 200032,China;Insititute of Medical Imaging of Shanghai,Shanghai 200032,China)

机构地区：[1]复旦大学附属中山医院核医学科,上海200032 [2]复旦大学核医学研究所,上海200032 [3]上海市影像医学研究所,上海200032

出　　处：《中国临床医学》2020年第5期750-755,共6页Chinese Journal of Clinical Medicine

基　　金：上海市临床重点专科项目(shslczdzk03401);西门子医疗科技有限公司资助项目(H2019-101).

摘　　要：目的:探讨骨显像单光子发射计算机体层成像/计算机体层成像(SPECT/CT)骨定量分析国人脊柱及骨盆的标准化摄取值(SUV)的正常分布。方法:回顾性分析500例入组肿瘤骨转移患者的锝[99mTc]-亚甲基二磷酸盐(99mTc-MDP)骨定量SPECT/CT显像数据。在正常颈、胸、腰、骶椎及骨盆骨骼处勾画感兴趣区,测量最大(maximum)和平均(mean)SUV(SUVmax和SUVmean),统计分析SUV值在正常骨骼的分布及其与年龄、身高、体质量和CT值的相关性。结果:SUVmax和SUVmean在第6颈椎最大,分别为7.4±2.5和6.0±2.2,在第3骶椎最小,分别为4.4±2.0和2.2±1.1。脊柱及骨盆SUVmax和SUVmean的变异系数(CV)大小相近,分别在31.6%~45.6%和34.1%~52.7%,骨盆组成骨SUVmax(CV骨盆=42.4%、CV脊柱=35.0%)和SUVmean(CV骨盆=52.7%、CV脊柱=38.3%)个体间差异略大于脊柱。骨骼SUV值在不同性别间无统计学差异。脊柱及骨盆的SUVmax和SUVmean与身高均无显著相关性,与年龄负相关,与体质量及CT值正相关。结论:骨定量SPECT/CT可获得99mTc-MDP在正常骨骼中的SUV值,可用于骨转移诊断及评估的参考;不同部位骨骼SUV值存在一定差异,应用SUV值诊断和评估肿瘤骨转移时需具体部位具体分析。Objective:To study the normal distribution characteristics of standardized uptake value(SUV)of spine and pelvis with 99m Tc-methylene diphosphate(99m Tc-MDP)in Chinese people underwent single photon emission computed tomography/computed tomography(SPECT/CT)imaging.Methods:A total of 500 enrolled patients with cancer undergoing bone quantitative SPECT/CT with 99m Tc-MDP.The maximum and mean SUV(SUV max and SUV mean)were measured.Furthermore,the distribution of SUV in normal bone and its correlation with age,height,weight,and the CT value were assessed.Results:The maximum SUV max and SUV mean were in the sixth cervical vertebra with 7.4±2.5 and 6.0±2.2 respectively,and the minimum in the third sacral vertebra with 4.4±2.0 and 2.2±1.1 respectively.The coefficient of variation(CV)of SUV max and SUV mean in spine and pelvis were similar,ranging from 31.6%to 45.6%and 34.1%to 52.7%respectively.The variation between individuals of SUV max(CV pelvis=42.4%,CV spine=35.0%)and SUV mean(CV pelvis=52.7%,CV spine=38.3%)in pelvis were slightly larger than that of spine.There was no significant difference between male and female.There was no significant correlation between SUV max and SUV mean of spine and pelvis and height.In addition,both SUV max and SUV mean showed negative correlation with age,and positive correlation with weight and CT values.Conclusions:The SUV of 99m Tc-MDP in normal bone can be obtained by bone quantitative SPECT/CT,which can reflect the mineral metabolism of bone and be used as a reference for the diagnosis and evaluation of bone metastasis.There are some differences in the SUV of different parts of bone.The application of SUV in diagnosing and evaluating bone metastasis should be region specified.

关 键 词：单光子发射计算机体层成像 计算机体层成像 标准化摄取值 99mTc-亚甲基二磷酸盐 

分 类 号：R817.4[医药卫生—影像医学与核医学]