抗病毒转基因鸡研究概况  

Advance in Transgenic Chickens with Virus Resistance

作　　者：乔延召 李清华 白银山 封柯宇[1] 谢青梅[1] QIAO Yan-zhao;LI Qing-hua;BAI Yin-shan;FENG Ke-yu;XIE Qing-mei(College of Animal Science,South China Agricultural University,Guangzhou,Guangdong,510642,China;School of Life Sciences and Engineering,Foshan Institute of Science and Technology,Foshan,Guangdong,528231,China)

机构地区：[1]华南农业大学动物科学学院,广东广州510642 [2]佛山科学技术学院生命科学与工程学院,广东佛山528231

出　　处：《动物医学进展》2020年第11期117-121,共5页Progress In Veterinary Medicine

基　　金：广东省农业产业技术体系首席专家项目(2019KJ128);广东省黄羽肉鸡基因组育种研究项目(2018B020203001);广东省国家现代农业产业科技创新项目(2018kczx01);广东省重大疫病疫苗研究项目(2019B020218004)。

摘　　要：鸡传染性疾病的频繁暴发,不仅危害养禽业,某些高致病性病毒,如高致病性禽流感病毒还能感染人类,直接威胁到人类健康。针对病毒性疾病,从种源入手,加快家禽育种的步伐,培育出抗病新品种,才能从根本上解决问题。转基因技术的应用为提高育种效率提供了更快捷的手段。论文对转基因鸡的制备方法,如病毒载体法、生殖细胞基因修饰法、受体器官移植法进行综述,其次进行禽流感、传染性支气管炎等病毒病抗性转基因鸡研究现状的展示。Frequent outbreaks of infectious diseases in chickens not only harm the poultry industry,some highly pathogenic viruses,such as avian influenza virus(AIV)can also infect humans,directly threatening human health.In view of viral diseases,it is necessary to accelerate the pace of poultry breeding and develop new disease-resistant varieties from the provenance so as to fundamentally solve the problem.The application of transgenic technology just provides a faster way to improve the breeding efficiency.Firstly,the pre-paration methods of transgenic chickens,such as virus vector method,germ cell gene modification method and recipient organ transplantation method were reviewed in the paper;Secondly,the research status of transgenic chickens with resistance to avian influenza,infectious bronchitis(IB)and other virus diseases was demonstrated.Finally,the prospect of the subject is made to promote the application and development of disease resistant breeding in poultry.

关 键 词：转基因 抗病毒 发展趋势 鸡 

分 类 号：S831.2[农业科学—畜牧学]