血尿酸血清PA水平与SLE疾病活动度及肾损害的关系  

Relationship between Serum Uric Acid and Serum PA Levels and SLE Activity and Kidney Damage

作　　者：黄志鹏[1] 亓涛[1] 赵明海[1] HUANG Zhipeng;QI Tao;ZHAO Minghai(Southern Hospital of Southern Medical University, Guangdong Guangzhou 510515, China)

机构地区：[1]南方医科大学南方医院检验科,广东广州510515

出　　处：《河北医学》2020年第11期1858-1864,共7页Hebei Medicine

基　　金：广东省教育厅,校企合作创新创业教育综合改革项目,(编号:PROJ99761503462660)。

摘　　要：目的:探究血尿酸、血清前白蛋白(PA)水平与系统性红斑狼疮(SLE)疾病活动度及肾损害的关系。方法:回顾性选取2016.1月至2019.12月本院诊治的SLE患者66例为研究对象,按SLE疾病活动性指数(SLEDAI)评分分为轻度活动组(25)、中度活动组(21)、重度活动组(20)。比较三组患者临床资料、血尿酸、血清PA之间的差异,并采用Logistic回归分析血尿酸、血清PA与SLE活动度及肾损害的关系。结果:血尿酸水平SLE轻度活动组<中度活动组<重度活动组,血清PASLE轻度活动组>中度活动组>重度活动组,组间差异均具有统计学意义(P<0.05)。Pearson相关性结果显示,血尿酸与SLEDAI评分呈显著正相关(P<0.01),血清PA与SLEDAI评分呈显著负相关(P<0.01)。另66例SLE患者中共有46例合并LN,其中肾功能正常者占56.52%(26/46),肾功能异常占43.48%(20/46)。单因素结果显示,肾功能正常、异常组患者的Hb、TG、eGFR、Scr、血尿酸差异具有统计学意义(P<0.05),而两组间血清PA水平差异无统计学意义(P>0.05)。二元Logistic回归分析显示,Hb、TG、eGFR及血尿酸均为LN患者肾损害的相关影响因素(B=-3.126、3.623、-4.143、4.464,P<0.05)。结论:血尿酸、血清PA均与SLE疾病活动度关系密切,二者均可作为SLE活动性的指标;另血尿酸是肾损害的相关影响因素,而未发现肾损害与血清PA之间的相关性。Objective:To investigate the relationship between serum uric acid and serum prealbumin(PA)levels and the degree of activity and kidney damage in systemic lupus erythematosus(SLE).Methods:66 SLE patients diagnosed and treated in our hospital from January 2016 to December 2016 were retrospectively selected as the study subjects.According to the SLEDAI score,they were divided into the mildly active group(25),the moderately active group(21),and the severely active group(20).The differences in clinical data,serum uric acid and serum PA among the three groups were compared,and the relationship between serum uric acid and PA with SLE activity and kidney damage was analyzed by Logistic regression.Results:Serum uric acid level SLE mild activity group<moderate activity group<severe activity group,serum PASLE mild activity group>moderate activity group>severe activity group,the differences between the groups were statistically significant(P<0.05).Pearson's correlation results showed that serum uric acid was positively correlated with SLEDAI score(P<0.01),and serum PA was negatively correlated with SLEDAI score(P<0.01).Among the other 66 SLE patients,46 had LN,of which 56.52%(26/46)had normal renal function and 43.48%(20/46)had abnormal renal function.Single-factor results showed that the differences of Hb,TG,eGFR,Scr and serum uric acid in the normal and abnormal renal function groups were statistically significant(P<0.05),while the differences of serum PA level between the two groups were not statistically significant(P>0.05).Binary Logistic regression analysis showed that Hb,TG,eGFR and serum uric acid were all related influencing factors for renal damage in patients with LN(B=-3.126,3.623,-4.143,4.464,P<0.05).Conclusion:Serum uric acid and serum PA are closely related to the activity level of SLE,both of which can be used as indicators of SLE activity.Serum uric acid was a related factor of renal damage,but no correlation between renal damage and serum PA was found.

关 键 词：系统性红斑狼疮 肾损害 活动度 血尿酸 血清前白蛋白 

分 类 号：R593.241[医药卫生—内科学]