小儿先天性心脏病血清TGF-β1CTGF与心肌重塑的关系  

Correlation Between Serum TGF-β1 and CTGF and Myocardial Remodeling in Children with Congenital Heart Disease

作　　者：左茜 魏东明 苏征 程润润 彭岚刚 ZUO Qian;WEI Dongming(The First Affiliated Hospital of Air Force Medical University / Xijing Hospital, Shanxi Xi'an 710032, China)

机构地区：[1]空军军医大学第一附属医院/西京医院心血管外科,陕西西安710032 [2]空军军医大学第二附属医院/唐都医院检验科,陕西西安710038

出　　处：《河北医学》2020年第11期1923-1927,共5页Hebei Medicine

基　　金：陕西省人才创新推进计划项目,(编号:2017KJXX-07)。

摘　　要：目的:分析小儿先天性心脏病(CHD)血清转化生长因子-β1(TGF-β1)、结缔组织生长因子(CTGF)与心肌重塑的关系。方法:回顾性分析我院2017年5月至2019年12月186例CHD患儿临床资料,根据其心力衰竭(简称心衰)发生情况分为CHD心衰组及CHD无心衰组,比较两组血清TGF-β1、CTGF水平;并根据纽约心脏病协会(NYHA)心功能分级将CHD心衰组分为NYHAⅡ组、NYHAⅢ组、NYHAⅥ组,比较三组心肌重塑指标[LADI、LVEDDI、LVEDVI、LVMI]及血清TGF-β1、CTGF水平差异,并使用Pearson相关分析评估血清TGF-β1、CTGF水平与心肌重塑的相关性。结果:186例CHD患儿伴心衰129例,纳入CHD心衰组;无心衰57例,纳入CHD无心衰组;两组性别、年龄、病因等基线资料比较,差异无统计学意义(P>0.05);CHD心衰组血清TGF-β1、CTGF水平明显高于CHD无心衰组(P<0.05)。129例CHD患儿伴心衰患儿中,NYHAⅡ39例,纳入NYHAⅡ组;NYHAⅢ56例,纳入NYHAⅢ组;NYHAⅥ34例,纳入NYHAⅥ组;三组LADI、LVEDDI、LVEDVI、LVMI及血清TGF-β1、CTGF水平比较,均为NYHAⅡ组<NYHAⅢ组<NYHAⅥ组(P<0.05);经Pearson相关分析,发现血清TGF-β1、CTGF水平与LADI、LVEDDI、LVEDVI、LVMI呈正相关(P<0.05)。结论:血清TGF-β1、CTGF与小儿CHD心肌重塑程度具有相关性,在评估患儿心肌重塑状况中有一定应用价值。Objective:To analyze the correlation between serum transforming growth factor-β1(TGF-β1)and connective tissue growth factor(CTGF)and myocardial remodeling in children with congenital heart disease(CHD).Methods:The clinical data of 186 children patients with CHD from May 2017 to December 2019 in our hospital were analyzed retrospectively.The children patients were divided into CHD heart failure group and CHD non-heart failure group according to the occurrence of heart failure.Serum TGF-β1 and CTGF levels were compared between the two groups.According to the New York Heart Disease Association(NYHA)heart function grading,the children patients in CHD heart failure group were divided into NYHAⅡgroup,NYHAⅢgroup and NYHAⅥgroup,and the myocardial remodeling indexes[LADI,LVEDDI,LVEDVI,LVMI]and levels of serum TGF-β1 and CTGF were compared among the three groups,and Pearson correlation analysis was used to evaluate the correlation between serum TGF-β1 and CTGF levels and myocardial remodeling.Results:Among 186 children patients with CHD,129 cases with heart failure were included in CHD heart failure group,and 57 cases without heart failure were included in CHD non-heart failure group.There were no statistically significant differences between the two groups in the baseline data such as gender,age and etiology(P>0.05).Serum TGF-β1 and CTGF levels in CHD heart failure group were significantly higher than those in CHD non-heart failure group(P<0.05).Among 129 children patients with CHD and heart failure,39 cases with NYHA gradeⅡwere included in NYHAⅡgroup,and 56 case with NYHA gradeⅢwere included in NYHAⅢgroup,and 34 cases with NYHA grade VI were included in NYHA VI group.Comparison of LADI,LVEDDI,LVEDVI,LVMI and serum TGF-β1 and CTGF levels showed that NYHAⅡgrouP<NYHAⅢgrouP<NYHAⅥgroup(P<0.05).Pearson correlation analysis found that serum TGF-β1 and CTGF levels were positively correlated with LADI,LVEDDI,LVEDVI and LVMI(P<0.05).Conclusion:Serum TGF-β1 and CTGF are closely related to the myocardial

关 键 词：先天性心脏病 心肌重塑 TGF-Β1 CTGF 心衰 

分 类 号：R725.4[医药卫生—儿科]