Flexible microbubble-based Fabry-Pérot cavity for sensitive ultrasound detection and wide-view photoacoustic imaging  

作　　者：JUN MA YANG HE XUE BAI LI-PENG SUN KA CHEN KYUNGHWAN OH BAI-OU GUAN 

机构地区：[1]Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications,Institute of Photonics Technology,Jinan University,Guangzhou 511443,China [2]Photonic Device Physics Laboratory,Department of Physics,Yonsei University,Seoul 033722,South Korea

出　　处：《Photonics Research》2020年第10期1558-1565,共8页光子学研究（英文版）

基　　金：Guangzhou Scicnce and Technology Plan Project(201904020032);The Local Innowative and Research leams Project of Guangdong Pearl River Talents Program(2019BT02X105);National Natural Science Foundation of China(61705082,U1701268);Natural Science Foundation of Guangdong Province(2017A030313361,2018030310587);Fundlamental Research Funds for the Central Universiies(21617304);Province High-Level Talents Introduction Plan(2017GCO10420).

摘　　要：Interaction of acoustic waves and microbubbles occurs in numerous biomedical applications including ultrasound imaging,drug delivery,lithotripsy treatment,and cell manipulation,wherein the acoustically driven microbub-blcs routincly act as active microscale oscillators or actuators.In contrast,microbubbles were utilized here as passive reccivers to detect broadband ultrasound waves in aqueous environments.The microbubble was photo-thermally generated on a microstructured optical fiber(MOF)tip,forming a flexible Fabry-Perot cavity whose gas-water interface was sensitive to ultrasound waves.The MOF severed as both a low-loss waveguide and a compact light condenser,allowing high-efficiency generation and stabilization of ultrasmall microbubbles.Integrated with all-fiber interferometry,a 10 um diameter microbubble exhibited a low noise-cquivalcnt pressur elevei of^3.4 mPa/Hz^1/2 and a broad bandwidth of^0.8 MHz,capable of detecting weak ultrasounds emittedfrom red blood cells irradiated by pulsed laser light.With advantages of high sensitivity,compact size,and low cost,the microbubble-based ultrasound sensor has great potential in biomedical imaging and sensing applications.

关 键 词：microstructure BUBBLE CAVITY 

分 类 号：TP212[自动化与计算机技术—检测技术与自动化装置]