我国绝经后骨质疏松病人影响因素的Meta分析  

Influencing factors of postmenopausal osteoporosis in China:a Meta-analysis

作　　者：易子涵 李茜 张海茹 杨良琴 鞠梅 YI Zihan;LI Qian;ZHANG Hairu;YANG Liangqin;JU Mei(School of Nursing,Southwest Medical University,Sichuan 646000 China)

机构地区：[1]西南医科大学护理学院,646000 [2]四川大学华西医院老年医学中心,610041

出　　处：《循证护理》2020年第11期1135-1141,共7页Chinese Evidence-Based Nursing

基　　金：国家社会科学基金项目,编号:16XSH017。

摘　　要：[目的]探讨绝经后骨质疏松(postmenopausal osteoporosis,PMOP)病人的影响因素,为其预防提供理论依据。[方法]计算机检索PubMed、EMbase、Web of Science、the Cochrane Library、中国知网(CNKI)、维普(VIP)、万方(WanFang Data)、中国生物医学文献数据库(CBM),检索日期为建库至2019年12月31日,全面收集有关绝经后PMOP病人影响因素的分析性研究,主要采用RevMan 5.3软件进行定量综合分析。[结果]共纳入5篇文献,均为病例对照研究,病例组1172例,对照组1474例,累计2646例调查对象。从文献中提取出对PMOP有预测价值的6个影响因素,分别为体质指数(BMI)[OR=0.83,95%CI(0.79,0.87)]、体育锻炼[OR=0.40,95%CI(0.20,0.81)]、绝经年限[OR=4.70,95%CI(1.93,11.41)]、哺乳时长[OR=2.91,95%CI(1.53,5.51)]、产次[OR=2.18,95%CI(1.51,3.15)]、年龄[OR=1.11,95%CI(1.08,1.14)],以上结果均有统计学意义(P<0.05),常饮茶因素合并后的OR值[OR=0.81,95%CI(0.17,3.95)无统计学意义(P>0.05)。[结论]现有证据表明,BMI、体育锻炼是PMOP的保护因素,绝经年限、哺乳时长、产次、年龄是PMOP的危险因素,常饮茶对PMOP的预测作用有待进一步探讨。护理人员应对以上因素予以重点关注,采取有效的措施延缓PMOP的发生。Objective:To explore the influencing factors of postmenopausal osteoporosis and to provide a theoretical basis for their prevention.Method:Analytical studies about the risk factors for PMOP were retrieved from China National Knowledge Infrastructure(CNKI),Wanfang Data,VIP,China Biology Medicine(CBM),and PubMed,Web of Science,the Cochrane Library,EMbase.The retrieval time was from the establishment of the database to December 31,2019.Quantitative comprehensive analysis was performed by Revman 5.3 software.Rusults:A total of 5 literatures were included,all of which were case-control studies.There were 1172 cases in the case group,1474 in the control group,and a total of 2646 cases were investigated.6 influential factors that have predictive value for PMOP were extracted from the literature,including BMI[OR=0.83,95%CI(0.79,0.87)],physical exercise[OR=0.40,95%CI(0.20,0.81)],menopause duration[OR=4.70,95%CI(1.93,11.41)],lactation duration[OR=2.91,95%CI(1.53,5.51)],parity[OR=2.18,95%CI(1.51,3.15)],and age[OR=1.11,95%CI(1.08,1.14)],the above results were statistically significant(P<0.05),and there was no significant difference in the combination of frequent drinking tea factors[OR=0.81,95%CI(0.17,3.95)].Conclusion:The current evidences shows that BMI and physical exercise are protective factors of PMOP.Menopausal duration,menopause years,lactation time,parity and age are risk factors of PMOP.The predictive effect of regular tea on PMOP needed to be further explored.Nursing staff should pay attention to the above factors and take effective measures to delay the occurrence of PMOP.

关 键 词：绝经后骨质疏松 危险因素 绝经年限 哺乳时长 产次 年龄 护理 META分析 系统评价 

分 类 号：R47[医药卫生—护理学]