SMTN基因多态性rs2074738与慢性阻塞性肺疾病急性加重的相关性研究  

Association between SMTN gene polymorphism rs2074738 and acute exacerbation of chronic obstructive pulmonary disease

作　　者：王蔚 杨青[1] 况九龙[1] 叶小群[1] WANG Wei;YANG Qing;KUANG Jiulong(Department of Respiratory&Intensive Care,the Second Hospital Affiliated Nanchang University,Nanchang,330006,China)

机构地区：[1]南昌大学第二附属医院呼吸与危重症医学科,南昌330006

出　　处：《江西医药》2020年第11期1545-1547,1555,共4页Jiangxi Medical Journal

基　　金：国家自然科学基金,编号81860011。

摘　　要：目的探讨SMTN基因多态性与慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者发生急性加重的相关性。方法选择2017年1月至2017年8月COPD患者268例进行前瞻性观察队列研究。入组患者均采集临床特征资料,通过1年随访发现有94例急性加重患者。比较两组的一般资料、超声心动图及SMTN单核苷酸多态性。结果在不同严重程度的COPD患者中显示,SMTN基因单核苷酸多态性rs2074738 GG基因型与COPD急性加重相关。rs2074738的GG基因型在总体人群(OR=2.613,95%CI=1.059-6.444,P=0.037)、特别是男性患者(OR=4.091,95%CI=1.358-12.318,P=0.0123)之间有显著性差异。结论经过1年随访,首次证实SMTN rs2074738的GG基因型可能是中国老年男性COPD患者病情恶化的独立标志物。Objective To investigate the relationship between SMTN gene polymorphism and acute exacerbation in patients with chronic obstructive pulmonary disease(COPD).Methods 268 COPD patients from January 2017 to August 2017 were enrolled for a prospective cohort study.Clinical data were collected in all the patients,and 94 patients with acute exacerbation were found after one year follow-up.The general data,echocardiography and single nucleotide polymorphism of SMTN were compared between the two groups.Results The single nucleotide polymorphism rs2074738 GG genotype of SMTN gene was associated with acute exacerbation of COPD in patients with different severity.The GG genotype of rs2074738 was significantly different among the general population(OR=2.613,95%CI=1.059-6.444,P=0.037),especially among male patients(OR=4.091,95%CI=1.358-12.318,P=0.0123).Conclusion The GG genotype of SMTN rs2074738 was first confirmed to be an independent marker of the deterioration of COPD in elderly male patients in China after one-year follow-up.

关 键 词：SMTN 单核苷酸多态性 慢性阻塞性肺疾病 

分 类 号：R563.9[医药卫生—呼吸系统]