泡脚方联合口服西药治疗2型糖尿病周围神经病变的临床观察  

Clinical Observation on Treatment of Type 2 Diabetic Peripheral Neuropathy with Paojiao Recipe and Oral Western Medicine

作　　者：金艺璇 吴卫明 钱玲玲 陈晓[1] 韩佳妮[1] JIN Yi-xuan;WU Wei-ming;QIAN Ling-ling;CHEN Xiao;HAN Jia-ni(Department of Endocrinology,Changshu Traditional Chinese Medicine Hospital,Nanjing University of Traditional Chinese Medicine,Changshu Jiangsu 215500)

机构地区：[1]南京中医药大学附属常熟市中医医院内分泌科,江苏常熟215500

出　　处：《世界中西医结合杂志》2020年第9期1675-1679,共5页World Journal of Integrated Traditional and Western Medicine

基　　金：江苏省卫生计生委科研课题立项项目(H2017512)。

摘　　要：目的研究泡脚方联合甲钴胺治疗2型糖尿病周围神经病变的临床疗效。方法选取2019年1月—2019年12月期间于南京中医药大学附属常熟市中医医院内分泌科就诊的80例2型糖尿病DPN患者,按随机数字表法分为对照组和治疗组各40例,对照组采用甲钴胺治疗,治疗组采用泡脚方联合甲钴胺进行治疗,总疗程60 d。疗程结束后统计分析治疗前后两组临床总疗效、神经症状发生情况、神经传导速度,以及血液流变学指标的变化情况。结果治疗2个月后,对照组患者的临床有效率为65.0%(26/40),治疗组患者的临床总有效率为92.5%(37/40),两组比较差异有统计学意义(P<0.05)。治疗后两组患者神经症状积分均低于治疗前(P<0.05);且治疗组症状积分均低于对照组(P<0.05)。治疗后两组患者正中神经MNCV、SNCV,腓总神经MNCV、SNCV均显著高于治疗前(P<0.05);且治疗组患者正中神经MNCV、SNCV,腓总神经MNCV、SNCV均显著高于对照组(P<0.05)。治疗后两组患者血液流变学指标纤维蛋白原、血浆黏度与红细胞积压指标均显著低于治疗前(P<0.05);且治疗组纤维蛋白原、血浆黏度与红细胞积压指标均显著低于对照组(P<0.05)。结论泡脚方联合甲钴胺治疗可提高2型糖尿病周围神经病变的临床总疗效,缓解糖尿病周围神经病变患者四肢疼痛、发凉等临床症状,提高神经传导功能,改善血液流变学指标,从而提升患者生活质量。Objective To study the clinical observation on the treatment of type 2 diabetic peripheral neuropathy with the combination of Paojiao Recipe and mecobalamin.Methods From January 2019 to December 2019,80 patients with type 2 diabetes with DPN who attended the Endocrinology Department of Changshu Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Traditional Chinese Medicine were divided into a control group and a treatment group with 40 cases each according to a random number table.After treatment,the control group was treated with mecobalamin,and the treatment group was treated with Paojiao Recipe and mecobalamin.The total course of treatment was 60 days.After the course of treatment,the total clinical curative effect,the occurrence of neurological symptoms,nerve conduction velocity,and changes in blood rheology indexes of the two groups before and after the treatment were counted.Results After 2 months of treatment,the clinical effective rate of patients in the control group was 65.0%(26/40),and the total clinical effective rate of patients in the treatment group was 92.5%(37/40).The difference between the two groups was statistically significant(P<0.05).After treatment,the neurosymptom scores of the two groups were lower than before treatment(P<0.05);and the symptom scores of the treatment group were lower than those of the control group(P<0.05).After treatment,the median nerve MNCV,SNCV,common peroneal nerve MNCV,and SNCV of the two groups of patients were significantly higher than before treatment(P<0.05);and the median nerve MNCV,SNCV,common peroneal nerve MNCV and SNCV of the treatment group were significantly higher than those of the control group Group(P<0.05).After treatment,the hemorheological indexes of fibrinogen,plasma viscosity and red blood cell pressure of the two groups of patients were significantly lower than before treatment(P<0.05);and the indexes of fibrinogen,plasma viscosity and red blood cell pressure of the treatment group were significantly lower than those of

关 键 词：泡脚方 2型糖尿病 周围神经病变 甲钴胺 神经症状 神经传导速度 血液流变学 

分 类 号：R587.2[医药卫生—内分泌] R244.9[医药卫生—内科学]