超声下两种硬化剂治疗复发性卵巢子宫内膜异位囊肿的对比  

The Clinical Effect of Ultrasound-guided Lauromacrogol Injection in the Treatment of Recurrent Ovarian Endometriosis Cysts

作　　者：张芳霞[1] 邹大中[1] 陆茹娟 ZHANG Fangxia;ZOU Dazhong;LU Rujuan(Department of Ultrasound,Jiangyin People’s Hospital,Jiangyin JiangSu 214400,China;Department of Gynaecology and Obstetrics,Jiangyin People’s Hospital,Jiangyin JiangSu 214400,China)

机构地区：[1]江阴市人民医院超声科,江苏江阴214400 [2]江阴市人民医院妇产科,江苏江阴214400

出　　处：《中国卫生标准管理》2020年第21期97-101,共5页China Health Standard Management

摘　　要：目的对比超声引导下聚桂醇和无水乙醇硬化治疗复发性卵巢子宫内膜异位囊肿的临床效果。方法本研究收集从2013年1月—2019年6月来本院门诊就诊且资料完整的复发性卵巢子宫内膜异位囊肿的患者60例,其中聚桂醇组(30例)与乙醇组(30例),乙醇组采用医用乙醇硬化术治疗,聚桂醇组行超声引导下聚桂醇硬化术治疗,对两组患者的临床疗效、不良反应发生率进行比较,并对两组患者治疗前后的CA125、窦卵泡数、卵泡刺激素、黄体生成素、雌二醇和抗缪勒管激素值比较。结果治疗后1个月和3个月乙醇组患者的总有效率高于聚桂醇组,差异具有统计学意义(P<0.05);6个月两组治疗效果差异无统计学意义(P>0.05);治疗后两组患者的CA125值均低于治疗前,聚桂醇组的CA125值低于乙醇组,差异具有统计学意义(P<0.05);治疗前后两组的AFC、FSH、LH、E2和AMH值均在正常范围内;治疗中聚桂醇组醉酒样反应的发生率低于乙醇组,治疗3~7天后腹痛的发生率低于乙醇组,差异具有统计学意义(P<0.05)。结论超声引导下穿刺硬化治疗复发性卵巢子宫内膜异位囊肿临床效果显著,CA125对疗效评估具有参考意义,同时聚桂醇硬化治疗比无水乙醇硬化治疗不良反应的发生率更少。Objective To analyze the clinical effect of ultrasound-guided lauromacrogol injection in the treatment of recurrent ovarian endometriosis cysts.Methods In this study,60 cases who were diagnosed with recurrent ovarian endometriosis cyst were collected from January 2013 to June 2019,randomly divided into lauromacrogol group(30 cases)and ethanol group(30 cases),the patients in the ethanol group were treated with ethanol sclerotherapy,while the patients in the lauromacrogol group were treated with lauromacrogol injection under the guidance of ultrasound,then the clinical effect and the incidence of adverse reactions and recurrence rate were compared between the two groups,and the values of CA125,AFC,FSH,LH,E2 and AMH before and after treatment were compared between the two groups.Results The total effective rate after 1 and 3 months treatment in the ethanol group was higher than the lauryl alcohol group,the differences were statistically significant(P<0.05).There was no significant difference between the two groups after 6 months.After the treatment,the CA125 value in the two groups was lower than that before the treatment,and the CA125 value in the polyglycol group was lower than that in the alcohol group,the differences were statistically significant(P<0.05).Before and after treatment,AFC,FSH,LH,E2 and AMH were in the normal range.During the treatment,the incidence of drunken reaction in the lauromacrogol group was lower than that in the ethanol group,and the incidence of abdominal pain after 3 to 7 days of treatment was lower than that in the ethanol group,the differences were statistically significant(P<0.05).Conclusion The clinical effect of ultrasound-guided puncture sclerotherapy on recurrent ovarian endometriosis cyst is significant,CA125 has reference significance in the evaluation of curative effect,at the same time,the incidence of adverse reactions in the treatment of polysaccharide sclerotherapy is less than that of anhydrous ethanol sclerotherapy.

关 键 词：卵巢子宫内膜异位囊肿 复发性 超声检查 聚桂醇注射液 硬化治疗 卵巢功能 

分 类 号：R711[医药卫生—妇产科学]