绿原酸的药理作用及机制研究进展  

Advances in research on the pharmacological effects and mechanism of action of chlorogenic acid

作　　者：王庆华 杜婷婷 张智慧 季鸣 胡海宇 陈晓光 WANG Qing-hua;DU Ting-ting;ZHANG Zhi-hui;JI Ming;HU Hai-yu;CHEN Xiao-guang(Small-molecule Immuno-oncology Drug Discovery Key Laboratory of Chinese Academy of Medical Sciences,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)

机构地区：[1]中国医学科学院、北京协和医学院药物研究所,中国医学科学院小分子肿瘤免疫治疗药物研究重点实验室,北京100050

出　　处：《药学学报》2020年第10期2273-2280,共8页Acta Pharmaceutica Sinica

基　　金：重大新药创制科技重大专项(2016ZX09101017);创新工程-重大协同创新项目(2019-I2M-1-005);中国医学科学院医学与健康科技创新工程(2017-I2M-2-004);北京协和医学院研究生创新基金(2019-1007-13)。

摘　　要：近年来,随着绿原酸研究的不断拓展和深入,其在医药、化工和食品等领域被广泛应用,具有潜在的、广阔的应用前景。绿原酸作为一种水溶性酚类化合物,在植物界中分布广泛,展现出较强的生物活性和多方面的药理作用。本文拟从抗菌、抗病毒、抗肿瘤、抗氧化和抗炎以及治疗代谢类疾病等几个方面对绿原酸的药理作用及机制作一综述,旨在为绿原酸作用机制的深入研究以及作用靶点的确证提供重要的理论依据。In recent years,with rapid advances in chlorogenic acid(CGA)research,it has become widely used in medicine,the chemical industry and health care products,with the potential for broad application.CGA is a water-soluble phenolic natural product and is extensively distributed in a variety of plants.Numerous studies have shown that CGA has strong biological activities including antibacterial,antiviral,antitumor,antioxidative,antiinflammatory and metabolic regulatory activities.This review summarizes the pharmacological effects as well as the underlying mechanisms of CGA,providing an important theoretical basis for further research on CGA drug targets and potential mechanisms.

关 键 词：绿原酸 抗菌活性 抗病毒活性 抗肿瘤活性 抗氧化活性 抗炎活性 代谢调节活性 作用机制 

分 类 号：R966[医药卫生—药理学]