二硫代氨基甲酸酯及其衍生物在药物化学中的应用  

Application of dithiocarbamates and their derivatives in medicinal chemistry

作　　者：郭杰 张志鹏 程茂军 刘婧[2] 周维新 谢赛赛 GUO Jie;ZHANG Zhi-peng;CHENG Mao-jun;LIU Jing;ZHOU Wei-xin;XIE Sai-sai(National Pharmaceutical Engineering Research Center for Solid Preparation in Chinese Herbal Medicine,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China;School of Pharmacy,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China)

机构地区：[1]江西中医药大学中药固体制剂制造技术国家工程研究中心,江西南昌330004 [2]江西中医药大学药学院,江西南昌330004

出　　处：《药学学报》2020年第10期2330-2339,共10页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(21807052,81760622);江西省科技创新杰出青年人才培养计划(20192BCB23018);江西省自然科学基金资助项目(20192ACBL21034,20202BAB216042);南昌市“双百计划”人才项目。

摘　　要：二硫代氨基甲酸酯及其衍生物具有独特的分子结构,这使其具有广泛的生物活性,已经成为近年来化工和药学领域研究的重点。本文综述了二硫代氨基甲酸酯及其衍生物的结构、合成和其在抗氧化、抗病毒、抗菌、抗肿瘤和抗阿尔茨海默病方面的生物活性,并对其今后的发展做出了展望。Dithiocarbamates and their derivatives with unique molecular structures possess diverse biological activities,which have become the research focus in the chemical and pharmaceutical fields in recent years.Here,we will review the structures,synthesis as well as biological activities of dithiocarbamates and their derivatives in anti-oxidation,anti-virus,anti-bacterial,anti-tumor and anti-Alzheimer’s disease,and make a prospect for their development in the future.

关 键 词：二硫代氨基甲酸酯 结构 合成 生物活性 展望 

分 类 号：R916[医药卫生—药学]