贝达喹啉联合常规抗结核药物治疗耐多药肺结核的效果观察  

Observe the Effect of Bedaquiline Combined with Conventional Anti-tuberculosis Drugs in the Treatment of Multi-drug Resistant Pulmonary Tuberculosis

作　　者：吴浩宇 WU Haoyu(Department of Tuberculosis in Students and Children,the Tenth People's Hospital of Shenyang(Shenyang Chest Hospital),Shenyang 110044,China)

机构地区：[1]沈阳市第十人民医院(沈阳市胸科医院)学生儿童结核科,辽宁沈阳110044

出　　处：《中国医药指南》2020年第29期48-49,共2页Guide of China Medicine

摘　　要：目的观察贝达喹啉联合常规抗结核药物治疗耐多药肺结核的效果。方法研究时间2018年1月至2018年7月,符合耐多药肺结核的患者68例为研究对象,按照数字随机法分为两组,对照组采用常规抗结核药物,观察组在此基础上联合贝达喹啉。比较两组痰液菌转阴率、治疗效果及不良反应发生情况。结果治疗6个月后,对照组痰菌转阴率32.35%,观察组痰菌转阴率61.76%,差异有统计学意义,P<0.05。治疗12个月后,对照组治疗有效率58.82%,观察组治疗有效率85.29%,差异有统计学意义,P<0.05。两组不良反应发生情况比较差异无显著差异,P>0.05。结论贝达喹啉联合常规抗结核药物治疗耐多药肺结核效果显著,转阴率高,较为安全,为临床耐多药肺结核的治疗提供新思路。Objective To observe the effect of bedaquiline combined with conventional anti-tuberculosis drugs in the treatment of multi-drug resistant pulmonary tuberculosis.Methods From January 2018 to July 2018,68 patients with multidrug-resistant tuberculosis were selected as the research objects.They were divided into two groups according to the number random method.The control group was treated with conventional anti-tuberculosis drugs,and the observation group was combined with bedaquiline on this basis.The negative conversion rate of sputum bacteria,the treatment effect and the occurrence of adverse reactions were compared between the two groups.Results After 6 months of treatment,the negative conversion rate of sputum bacteria in the control group was 32.35%,and the negative conversion rate of sputum bacteria in the observation group was 61.76%.The difference was statistically significant,P<0.05.After 12 months of treatment,the effective rate of treatment in the control group was 58.82%,and that in the observation group was 85.29%,the difference was statistically significant,P<0.05.There was no significant difference in the occurrence of adverse reactions between the two groups,P>0.05.Conclusion Bedaquiline combined with conventional antituberculosis drugs has a significant effect in the treatment of multi-drug resistant pulmonary tuberculosis,with a high rate of negative conversion,and is relatively safe,providing new ideas for the clinical treatment of multi-drug resistant pulmonary tuberculosis.

关 键 词：耐多药肺结核 贝达喹啉 抗结核药物 转阴率 安全性 

分 类 号：R521[医药卫生—内科学]