56例HIV抗体免疫印迹试验不确定结果的随访分析  

Follow-up analysis on 56 cases of indeterminate results of Western blot for HIV antibody

作　　者：秦攀 李青[1] 杨晓亮[1] 邢燕[1] 余泽波[1] QIN Pan;LI Qing;YANG Xiaoliang;XING Yan;YU Zebo(Blood Transfusion Department,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院输血科,重庆400016

出　　处：《检验医学与临床》2020年第22期3279-3281,3284,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨HIV抗体确证试验,即免疫印迹试验(WB),不确定结果患者的转归特点。方法回顾性分析2017-2018年该院56例WB不确定结果患者的临床及随访资料,包括患者一般资料、筛查试验(酶联免疫吸附试验、化学发光免疫分析法、快速检测)结果、WB的带型结果及转归情况。结果56例HIV抗体WB不确定结果的患者中,33例完成随访。其中28例随访中转阳性,5例转阴性。33例完成随访的患者中,两种筛查试验均有反应与其中仅一种筛查试验有反应的转阳率分别为92.59%、50.00%;WB带型为2条带及以上者共19例,转阳率100.00%,带型为1条带的共14例,转阳率为64.29%。结论3种筛查试验中的任意两种有反应或WB结果为2条带及以上的确证试验不确定结果患者均提示有极高感染风险;只有一种筛查试验有反应或WB结果仅1条带的情况也提示有较高感染风险。Objective To explore the characteristics and outcomes of indeterminate Western-blot(WB)results for HIV antibody.Methods Retrospectively analyze on 56 cases of indeterminate WB results for HIV antibody in the hospital from 2017 to 2018.The general information,screening tests(ELISA,CIA,RT)and the WB results were followed up.Results In the 56 cases of indeterminate WB results for HIV antibody,33 cases were followed up,of which 28 cases returned positive and 5 cases returned negative.Among the 33 follow-up cases,the positive rates of response in two screening tests and in only one of the screening tests were 92.59% and 50.00% respectively.In 19 cases,the band type was 2 bands or more,and the fellow-up positive rate was 100.00%.The band type was 1 band in 14 cases,and the fellow-up positive rate was 64.29%.Conclusion Any two of the three screening tests with a response or indeterminate result with 2 or more bands indicates a very high risk of infection,while only one screening test has a response or indeterminate result with only 1 band also suggests a high risk of infection.

关 键 词：HIV抗体 不确定结果 免疫印迹试验 带型 转归 

分 类 号：R446.61[医药卫生—诊断学]