坤泰胶囊用于治疗卵巢储备功能低下有效性的Meta分析  

Efficacy of Kuntai capsule for treating ovarian reserve dysfunction:a Meta-analysis

作　　者：张宝丽[1] 张莉莉[1] 杨媛[1] 孙晓燕 杨柳[1] 王丽蓉[1] 张学红[1] Zhang Baoli;Zhang Lili;Yang Yuan;Sun Xiaoyan;Yang Liu;Wang Lirong;Zhang Xuehong(The Reproductive Medicine Special Hospital of the 1st Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第一医院生殖医学专科医院,730000

出　　处：《中华生殖与避孕杂志》2020年第9期750-755,共6页Chinese Journal of Reproduction and Contraception

基　　金：甘肃省自然科学基金(18JR3RA340)。

摘　　要：目的系统评价坤泰胶囊用于治疗卵巢储备功能低下的疗效。方法计算机检索中国知网、中国生物医学数据库、万方数据库、维普数据库、PubMed、EMbase数据库以及临床试验注册平台(https://clinicaltrials.gov/),搜索关于使用坤泰胶囊治疗卵巢储备功能低下的文献,检索时间为建库至2019年7月。由2位评价员独立进行文献筛选、信息提取和风险评价后,采用Rev Man 5.3软件进行Meta分析。结果最后纳入符合标准随机对照试验(RCT)的文献共14篇,共纳入1191例患者。Meta分析结果显示:坤泰胶囊干预组与对照组相比,对于患者治疗前后基础窦卵泡数(MD=0.83,95%CI=0.32~1.35,P=0.001)差异有统计学意义。两组血清抗苗勒管激素(AMH)水平(MD=0.11,95%CI=-0.04~0.26,P=0.14)和Kupperman评分(MD=-2.67,95%CI=-7.43~2.10,P=0.27)水平差异无统计学意义。结论坤泰胶囊用于治疗卵巢储备功能低下患者可以有效提高基础窦卵泡数,但是不能显著提升患者血清AMH水平及改善Kupperman评分。但受纳入研究的数量和质量限制,上述结论尚需要开展更多研究予以验证。Objective To systematically evaluate the efficacy of Kuntai capsule in the treatment of ovarian reserve dysfunction.Methods CNKI,CBM,Wanfang database,VIP database,PubMed,EMbase database,and clinical trail registration(https://clinicaltrials.gov/)were searched from inception to July 2019 to collect randomized controlled trials(RCTs)about Kuntai capsule in treatment of ovarian reserve dysfunction.Literatures ware screened independently by two evaluators.After information extraction and risk assessment,meta analysis was performed by Rev Man 5.3 software.Results A total of 14 radomized controlled trials(RCTs)involving 1191 patients were included.Meta analysis showed that there were significant differences in the number of antral follicle count(MD=0.83,95%CI=0.32-1.35,P=0.001)between Kuntai capsule group and control group.There was no significant difference in serum anti-Müllerian hormone(AMH)level(MD=0.11,95%CI=-0.04-0.26,P=0.14)and Kupperman score(MD=-2.67,95%CI=-7.43-2.10,P=0.27)between the two groups.Conclusion Kuntai capsule can effectively increase the number of antral follicle count for patients with ovarian reserve dysfunction,but there was no significant improvement in serum AMH level and it can not reduce the Kupperman score.However,due to the quantity and quality of the study,the above conclusions need to be verified by more research.

关 键 词：卵巢储备功能低下 卵巢早衰 卵巢功能 坤泰胶囊 META分析 

分 类 号：R271.9[医药卫生—中西医结合]