胺碘酮致周围神经病  

Amiodarone-induced peripheral neuropathy

作　　者：王冰[1] 王泉[1] 李进峰[1] 张媛[1] Wang Bing;Wang Quan;Li Jinfeng;Zhang Yuan(Department of Pharmacy,Weihai Municipal Hospital,Shandong Province,Weihai 264200,China)

机构地区：[1]山东省威海市立医院药剂科,威海264200

出　　处：《药物不良反应杂志》2020年第10期593-594,共2页Adverse Drug Reactions Journal

摘　　要：1例70岁女性患者在心房颤动射频消融术后开始服用利伐沙班(10 mg、1次/d)、盐酸胺碘酮(200 mg、3次/d,8 d后减量为200 mg、2次/d)、单硝酸异山梨酯缓释片(30 mg、1次/d)。治疗5 d后患者出现双腿无力,症状逐渐加重,15 d后发展为四肢无力,双臂上举受限,双手不能持物,双腿不能持久站立。肌电图检查示周围神经损伤。经辅助检查排除肿瘤、代谢、免疫和炎症等原因引起的周围神经病后,考虑为胺碘酮所致周围神经病变。停用胺碘酮,给予维生素B1、维生素B6、甲钴胺口服和硫辛酸注射液静脉滴注,10 d后患者症状明显改善。A 70-year-old female patient received oral rivaroxaban(10 mg once daily),amiodarone hydrochloride(200 mg thrice daily at the beginning and 200 mg twice daily 8 days later),and isosorbide mononitrate sustained release tablets(30 mg once daily)after radiofrequency ablation of atrial fibrillation.After 5 days of treatments,the patient developed weakness of both legs,which was gradually aggravated.Fifteen days later,the patient presented with weakness of the limbs,limited lifting of arms,inability to hold objects with hands,and inability to stand on legs for a long time.Electromyogram showed peripheral nerve damage.Peripheral neuropathy caused by tumor,metabolism,immunity,and inflammation were excluded by auxiliary examination,and the peripheral neuropathy caused by amiodarone was considered.Amiodarone was discontinued and oral vitamin B1,vitamin B6,and mecobalamin,and an IV infusion of thioctic acid were given.Ten days later,the patient′s symptoms were improved obviously.

关 键 词：胺碘酮 周围神经系统疾病 药物相关副作用和不良反应 

分 类 号：R969[医药卫生—药理学]