Kadsura coccinea:A rich source of structurally diverse and biologically important compounds  

作　　者：Yu-pei Yang Nusrat Hussain Liu Zhang Yan-zhe Jia Yu-qing Jian Bin Li Muhammad Iqbal Choudhary Atta-ur Rahman Wei Wang 

机构地区：[1]TCM and Ethnomedicine Innovation(&)Development International Laboratory,School of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,China [2]H.E.J.Research Institute of Chemistry,International Center for Chemical and Biological Sciences,University of Karachi,Karachi 75270,Pakistan

出　　处：《Chinese Herbal Medicines》2020年第3期214-223,共10页中草药（英文版）

基　　金：This work was financially supported by the Ministry of Science and Technology(2018YFC1707900 and 2018FYI 00703);National Natural Science Foundation of China(81874369,81803708 and 81673579);Hunan Provincial Natural Science Foundation(2018JJ2293);Key Research and Development Programs of Hunan Science and Technology Department(2018SK2113,2018SK2119,2018WK2081);College Graduate Research and Innovation Projects of Hunan Province of China(CX20190537).

摘　　要：Kadsura coccinea belongs to medicinally important genus Kadsura from the Schisandraceae family.It has been used in traditional Chinese medicine(TCM)for the treatment of rheumatoid arthritis and gastroenteric disorders.The initial phytochemical work focused on the identification of some structurally novel and diverse natural products,which turned the attention of many researchers towards this plant.Thus far,202 compounds have been reported in this plant.Lignans and terpenoids were found as the main chemical constituents of this plant.Some of the triterpenoids and sesquiterpenoids with novel structures are of particular interest for natural product researchers.The isolated compounds of this plant have shown different bioactivities including anti-tumor,anti-HIV,anti-inflammatory,nitric oxide(NO)production inhibitory and other pharmacological effects.This review systematically summarizes all the phytochemical and pharmacological work done so far on K.coccinea,and can be used as a reference for future research on this plant.

关 键 词：Kadsura coccinea(Lem.)A.C.Smith Heilaohu lignans PHARMACOLOGY rheumatoid arthritis TRITERPENOIDS 

分 类 号：R284.1[医药卫生—中药学]