6-羟基染料木素和6,8-二羟基染料木素的简便合成  

Convergent Synthesis of 6-Hydroxygenistein and 6,8-Dihydroxygenistein

作　　者：邵瑾 杨颖[1,2] 何蕾 马慧萍 贾正平 景临林 SHAO Jin;YANG Ying;HE Lei;MA Hui-ping;JIA Zheng-ping;JING Lin-lin(College of Pharmacy,Lanzhou University,Lanzhou 730000,China;Department of Pharmacy,The 940^th Hospital of Joint Logistics Support Force of PLA,Lanzhou 730050,China)

机构地区：[1]兰州大学药学院,甘肃兰州730000 [2]联勤保障部队第九四〇医院药剂科,甘肃兰州730050

出　　处：《合成化学》2020年第11期998-1002,共5页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(81872796,81202458);甘肃省自然科学基金资助项目(18JR3RA408,1308RJYA06);中国博士后科学基金资助项目(2012M521926)。

摘　　要：以鹰嘴豆芽素A为原料,通过溴代、甲氧基化和去甲基化三步反应合成了6-羟基染料木素(2b)和6,8-二羟基染料木素(3b),总产率分别为20%和40%,其结构经1H NMR,13C NMR,IR和HR-MS(ESI)表征。6-Hydroxy(2b)and 6,8-Dihydroxygenistein(3b)were synthesized via a three-step synthetic procedure,including bromination,methoxylation and demethylation,by using the commercially available biochanin A as the starting material.The total yield of the target compounds was 20%and 40%respectively.The structure was confirmed by 1H NMR,13C NMR,IR and HR-MS(ESI).

关 键 词：鹰嘴豆芽素A 6-羟基染料木素 6 8-二羟基染料木素 甲氧基化反应 去甲基化反应 合成 

分 类 号：O621.3[理学—有机化学]