三乙烯二胺催化的丙二腈与α,β-不饱和吡唑酰胺的共轭加成反应  

Conjugate Addition of Malononitrile to α,β-unsaturated N-Acylpyrazoles Medated by Triethylenediamine

作　　者：许宏明 李国伟 Xu Hongmin;Li Guowei(Dayan Middle School at Changyang Tujia autonomous county,Yichang 443508,China;Taizhou Elitechemie MediPharma Technology Co.,Ltd.,Taizhou 225300,China)

机构地区：[1]长阳土家族自治县大堰乡大堰初级中学,湖北宜昌443508 [2]泰州精英化成医药科技有限公司,江苏泰州225300

出　　处：《山东化工》2020年第21期32-34,共3页Shandong Chemical Industry

摘　　要：在三乙烯二胺的催化下,α,β-不饱和吡唑酰胺与丙二氰发生共轭加成反应,以50-81%的产率转化为加成产物。反应具有较好的底物适应范围,各种不同电子性质以及大位阻的α,β-不饱和吡唑酰胺都是合适的反应受体。所有的产物结构都经核磁氢谱确认,并与文献数据一致。加成产物能够顺利转化为相应的酰胺。A conjugate addition of malononitrile toα,β-unsaturated N-acylpyrazoles was established with triethylenediamine.Mediate to good isolated yields(50-81%)have been afforded withα,β-unsaturated N-acylpyrazoles with different electronic property and steric demand.The structures of products have been confirmed via 1H-NMR analysis.Adducts obtained via this approach could be smoothly converted into the corresponding amide.

关 键 词：共轭加成 α β-不饱和吡唑酰胺 丙二氰 三乙烯二胺 

分 类 号：O622[理学—有机化学] TQ22[理学—化学]