血小板-淋巴细胞比率、中性粒细胞-淋巴细胞比率及红细胞分布宽度在冠心病严重程度中的诊断价值  

Diagnostic value of platelet-lymphocyte ratio,neutrophil-lymphocyte ratio and red blood cell distribution width in the severity of coronary heart disease

作　　者：张林[1] 陈玥[1] 张宝红[1] ZHANG Lin;CHEN Yue;ZHANG Baohong(Department of Laboratory Medicine,Beijing Friendship Hospital,Capital Medical University,Beijing,100050,China)

机构地区：[1]首都医科大学附属北京友谊医院检验科,北京100050

出　　处：《临床心血管病杂志》2020年第9期824-827,共4页Journal of Clinical Cardiology

摘　　要：目的:探讨血小板-淋巴细胞比率(PLR)、中性粒细胞-淋巴细胞比率(NLR)及红细胞分布宽度(RDW)在冠心病(CHD)患者疾病严重程度中的诊断价值。方法:选取2018-05-2019-10在我院进行冠状动脉造影(CAG)检查的患者170例,根据检查结果分为CHD组(130例)与对照组(非CHD组,40例);并按冠状动脉狭窄程度(Gensini)积分,将130例CHD患者分为CHD低危组(45例)、CHD中危组(50例)及CHD高危组(35例)。比较4组研究对象PLR、NLR、RDW水平及Gensini积分,采用Pearson法分析PLR、NLR、RDW水平与Gensini积分相关性,采用受试者工作特征(ROC)曲线检测PLR、NLR、RDW指标单独及联合诊断对CHD患者病情严重程度的诊断价值。结果:3组CHD患者PLR、NLR及RDW水平均明显高于对照组(P<0.05),CHD患者Gensini积分、PLR、NLR及RDW水平均随病情严重程度的增加而上升(P<0.05);CHD患者PLR、NLR及RDW水平与Gensini积分呈正相关(r=0.439、0.431、0.573,P<0.05);PLR、NLR、RDW单独及联合诊断CHD患者病情严重程度的AUC值分别为0.782、0.776、0.767及0.875。结论:机体内PLR、NLR、RDW水平可作为评估冠状动脉病变程度的指标,与CHD患者病情严重程度密切相关。Objective:To explore the diagnostic value of platelet-lymphocyte ratio(PLR),neutrophil-lymphocyte ratio(NLR) and red blood cell distribution width(RDW) in the severity of coronary heart disease(CHD).Method:A total of 170 patients who underwent coronary angiography(CAG) from May.2018 to Oct.2019 were selected and divided into CHD group(n=130) and control group(Non-CHD group,n=40).According to the degree of coronary artery stenosis(Gensini) score,130 patients with CHD were divided into CHD low-risk group(n=45),CHD intermediate-risk group(n=50) and CHD high-risk group(n=35).The PLR,NLR,and RDW levels of four groups were compared,and the Pearson method was used to analyze the correlation.The receiver operating characteristic(ROC) curve was used.Result:The expression levels of PLR,NLR,and RDW in the three groups of CHD patients were significantly higher than those in the control group(P<0.05).The levels of Gensini score,PLR,NLR and RDW increased with the severity of CHD patients(P<0.05).PLR,NLR and RDW levels in patients with CHD were positively correlated with Gensini scores(r=0.439,0.431,0.573,P<0.05).The AUC values of PLR,NLR,RDW combined and separately diagnosed in patients with CHD were 0.782,0.776,0.767,and 0.875.Conclusion:The levels of PLR,NLR,and RDW in the body can be used as indicators to assess the degree of CHD,which is closely related to the severity of CHD patients.

关 键 词：冠心病 血小板-淋巴细胞比率 中性粒细胞-淋巴细胞比率 红细胞分布宽度 诊断价值 

分 类 号：R541.4[医药卫生—心血管疾病]