不同程度情感障碍的耳鸣患者静息态功能磁共振成像特点的研究  

Characteristics of resting state functional magnetic resonance imaging in tinnitus patients with different degrees of affective disorder

作　　者：王立志[1] 韩丽燕 卫来[1] 王志强[1] WANG Lizhi;HAN Liyan;WEI Lai;WANG Zhiqiang(Department of Otolaryngology,Affiliated Zhongshan Hospital of Dalian University,Dalian,116001,China;Department of Otolaryngology,the People’s Hospital of Xinzhou)

机构地区：[1]大连大学附属中山医院耳鼻喉科,辽宁大连116001 [2]忻州市人民医院耳鼻喉科

出　　处：《临床耳鼻咽喉头颈外科杂志》2020年第9期781-784,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:观察不同程度情感障碍的耳鸣患者与无耳鸣健康志愿者的静息态功能磁共振成像(rs-fMRI)的差异,分析因耳鸣导致的不同程度情感障碍与脑功能变化的相关性。方法:选取曾参与前期研究的耳鸣患者19例,同时选取同期无耳鸣的健康志愿者15例作为对照。根据耳鸣致残量表得分将患者分为轻度组和重度组。耳鸣患者与健康志愿者均采集rs-fMRI,利用DPABI软件对结果分别进行局部一致性(ReHo)分析、低频波动振幅(ALFF)分析和低频波动分数振幅(fALFF)分析获得ReHo值、ALFF值和fALFF值。将轻度组与对照组、重度组与对照组的ReHo值、ALFF值和fALFF值分别行双样本t检验。结果:与对照组比较,轻度组左枕中回的fALFF值高于对照组,差异有统计学意义(P<0.05),但ALFF值和ReHo值的差异无统计学意义;重度组右额上回、左颞中回、左额下回三角部和左尾状核的ALFF值明显高于对照组,差异有统计学意义(P<0.05),但2组fALFF值和ReHo值差异无统计学意义。结论:耳鸣导致的情感障碍程度不同时,脑功能异常区域不同。轻度情感障碍时可通过fALFF分析检出神经活动增高的脑区为左枕中回。重度情感障碍可通过ALFF分析检出神经活动增高的脑区为左颞中回、右额上回、左额下回三角部、左尾状核。Objective:To analyze the correlation of the degree of affective disorder and brain function changes by comparing the differences of resting-state functional Magnetic Resonance Imaging(rs-fMRI)between healthy volunteers without tinnitus and patients with tinnitus.Method:A analysis of 19 patients with tinnitus and 15 healthy volunteers without tinnitus.The patients were divided into mild group and severe group according to tinnitus handicap inventory(THI).Rs-fMRI was collected and the regional homogeneity(ReHo)analysis,amplitude of low-frequency fluctuation(ALFF)analysis,and fractional amplitude of low frequency fluctuation(fALFF)analysis of rs-fMRI were performed by DPABI software.Two-sample t-test of the ReHo value,ALFF value and fALFF value between the mild group and the control group,the severe group and the control group,were performed respectively.Result:The fALFF value of the left occipital gyrus in the mild group was higher than that in the control group,the difference was statistically significant(P<0.05),but there is no statistically significant difference of ALFF value and ReHo value between two groups.The ALFF value of the middle temporal gyrus(left),superior frontal gyrus(right),inferior frontal gyrus pars triangularis(left)and caudate nucleus(left)in the severe group were higher than those of the control group.But there was no significant difference in the fALFF value and the ReHo value.Conclusion:Different severity of affective disorder in patients with tinnitus have different areas of brain function abnormalities.Mild group was detected by fALFF analysis and the active brain area was the left middle occipital region.Severe group was detected by ALFF analysis.The active brain regions were left middle temporal gyrus,right superior frontal gyrus,left inferior frontal gyrus pars triangularis,and left caudate nucleus.

关 键 词：耳鸣 情感障碍 静息态功能磁共振成像 

分 类 号：R764.45[医药卫生—耳鼻咽喉科]